[PDF] Genome|wide association meta|analysis of corneal curvature ...

Genome-wide association studies for corneal and refractive ...

The largest study published to date was a GWAS meta-analysis for refractive astigmatism performed by Li et al. (2015), which had a sample of ...

Genome-wide Association Study of Axial Length in Population ...

This study identified 1478 SNPs spread over 31 loci. Of the 31 loci, 5 are known AL loci, 15 are known refractive-error loci, 4 are known corneal-curvature loci ...

A genome-wide association study of corneal astigmatism

Phenotyping, genotyping, and genetic imputation. Anterior corneal curvature was measured using keratometry (the keratometer used by each CREAM ...

Heritability and Genetic Factors of Astigmatism and Corneal Curvature

12. Li, Q ∙ Wojciechowski, R ∙ Simpson, CL ... Genome-wide association study for refractive astigmatism reveals genetic co- ...

Genetic Variants near PDGFRA Are Associated with Corneal ...

12-10489/-/. DCSupplemental). DISCUSSION. We have conducted a genomewide association study on corneal curvature in an Australian population of Northern.

Genetic Variants near PDGFRA Are Associated with Corneal ... - IOVS

... analysis of corneal curvature GWAS on Australians with ... Principal components analysis corrects for stratification in genome-wide association studies.

A multiethnic genome-wide analysis of 44,039 individuals identifies ...

Central corneal thickness (CCT) is one of the most heritable human traits, with broad-sense heritability estimates ranging between 0.68 to ...

CMPK1 and RBP3 are associated with corneal curvature in Asian ...

Despite the high heritability of CC, only two associated genes have been discovered to date. We performed a three-stage genome-wide association study meta- ...

Genome-wide association study for refractive astigmatism reveals ...

SNPs in the same region of PDGFRA have since been found to be associated with both corneal curvature and axial length (Han et al. 2011; ...

Association of Novel Loci With Keratoconus Susceptibility in a ...

This multitrait genome-wide association study used European ancestry data on corneal resistance factor from UK Biobank and the Canadian ...

GWAS in myopia - King's College London Research Portal

A genome-wide association study for corneal curvature identifies the ... functional analysis of gene lists from genome-wide association study results in 2.

Genome-wide association meta-analysis of 88250 individuals ...

We aim to examine shared genetic etiology in age-related macular degeneration (AMD), diabetic retinopathy (DR), glaucoma, retinal detachment (RD), and myopia.

Genome-wide Association Study of Axial Length in Population ...

Of the 31 loci, 5 are known AL loci, 15 are known refractive-error loci, 4 are known corneal- curvature loci, and 7 loci are newly identified ...

A multi-ethnic genome-wide association study implicates collagen ...

We have identified significant association with 36 genomic loci that, for the first time, implicate both dysregulation of corneal collagen matrix integrity and ...

Genome‐Wide Association Analysis Identifies LILRB2 Gene for ...

... corneal radius and curvature in the mice. By analyzing the reflection points of eight infrared LEDs on the corneal surface, the corneal ...

Heritability and Genetic Factors of Astigmatism and Corneal Curvature

Systematic review and meta-analysis (PROSPERO ID: CRD42023447370). Methods. Studies that reported the heritability and genetic associations of RA, CA and/or CC ...

A Study Linking Axial Length, Corneal Curvature, and Eye Axis With ...

This research aimed to determine the association linking axial length and corneal curvature with demographic characteristics in emmetropic eyes ...

In addition, none of the SNPs appeared significant for corneal curvature. Conclusions. Our study suggested a potential association of rs6795735 ...

A Transformative Concept: Central Corneal Thickness

in addition to corneal curvature and astigmatism, as well as ... Cross-ancestry genome- · wide association analysis of corneal thickness strengthens link.

Genome-Wide Meta-Analysis of Five Asian Cohorts Identifies ...

Our group recently reported a strong association between variants in PDGFRA with corneal curvature [38]. Corneal curvature is an ocular ...