A translational perspective on neural circuits of fear extinction

Parsing neural circuits of fear learning and extinction across basic ...

List of references · Bukalo, Prefrontal inputs to the amygdala instruct fear extinction memory formation, Sci. · Cai, Distinct signals in medial and lateral VTA ...

Fear extinction as a model for translational neuroscience: ten years ...

Approximately 10 years ago, however, there began a concerted effort to understand the neural circuits of extinction of fear conditioning, in both animals and ...

Neuronal circuits of fear extinction | Request PDF - ResearchGate

... Current models posit that neural circuits and cell assemblies for fear and extinction memories compete with one another, in a context-dependent manner, to ...

Unrelenting Fear Under Stress: Neural Circuits and Mechanisms for ...

A critical hub for extinction learning is centered in the medial prefrontal cortex (mPFC) and its connections with the hippocampus (HPC) and amygdala (Maren and ...

Translational neuroscience measures of fear conditioning across ...

This research has indicated that the amygdala, located in the brain limbic circuit in the temporal lobe, is necessary for fear-conditioned ...

Neural Circuit Mechanisms of Fear Extinction | Anxiety Disorders

Third, renewal of the cued fear response is seen when the animal is tested in a context different from that in which it was originally extinguished. These ...

Rodent models of impaired fear extinction | Psychopharmacology

These models have helped to reveal neurobiological correlates of extinction circuitry failure, gene variants, and other mechanisms underlying ...

Dopamine regulation of contextual fear and associated neural circuit ...

In contrast, longer or repeated context re-exposure alone results in contextual fear extinction, which is a form of inhibitory learning that ...

State-of-the-art and future directions for extinction as a translational ...

The translational value of extinction will be increased by more investigation of elements central to extinction itself, such as extinction generalization, ...

The translational neural circuitry of anxiety Abstract - UCL Discovery

Neural circuits and mechanisms involved in Pavlovian fear conditioning: A critical review. ... psychopharmacology: an ethological approach to the pharmacology of ...

Extinction, Deconsolidation, and Erasure of Fear Memory: Neuron

Although we do not yet understand the nature of the permanent changes in brain circuitry that maintain fear memory for the life of the organism, we now have an ...

Fear extinction requires ASIC1a-dependent regulation of ... - Science

In general, fear extinction is believed to represent a new learning (i.e., extinction learning) process that leads to the formation of ...

State-of-the-art and future directions for extinction as a translational ...

Pavlovian fear conditioning and extinction has proved to be an illuminating translational model for understanding and treating fears and anxiety ...

Neural Oscillatory Correlates for Conditioning and Extinction of Fear

... translational efforts aimed at fear extinction by neural oscillatory modulation ... Translational Perspectives. The relevance of neural ...

Dopamine neurons drive fear extinction learning by signaling ... - eLife

These results identify a prediction error-like neuronal signal that is necessary to initiate fear extinction and reveal a crucial role of DA ...

Neurobiological advances of learned fear in humans

Crucially, latest available evidence has identified the PFC as a critical core component in the neural circuit underlying fear conditioning, particularly for ...

Stimulation of an entorhinal-hippocampal extinction circuit facilitates ...

Fear extinction primarily relies on tripartite cortical-subcortical neural circuits, including medial prefrontal cortex (mPFC), basolateral ...

Fear extinction rescuing effects of dopamine and L-DOPA in ... - Nature

These data indicate that systemic L-DOPA treatment produces an extinction-related increase in neuronal activity in a specific subset of IL, but ...

Uncertainty-Dependent Extinction of Fear Memory in an Amygdala ...

To address this question, we focused on neural processing in the amygdala and mPFC during fear conditioning and extinction. We developed a neural circuit model ...

Impaired Fear Extinction Learning and Cortico-Amygdala Circuit ...

To elucidate the neural basis of impaired 129S1 fear extinction, c-Fos and Zif268 expression was mapped after extinction recall. Results showed ...