Adrenergic Receptors — Evolving Concepts and Clinical Implications

Adrenergic Receptors in Cognition, Cardioprotection, and Metabolism

The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH, United States. The α1-adrenergic receptors (ARs) are G-protein coupled ...

Norepinephrine Increases Alveolar Fluid Reabsorption and Na,K ...

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Update on current concepts of the molecular basis of β 2 -adrenergic ...

... receptors, can be used for gene therapy with highly specific effects. (J ... receptor with unique properties would provide the greatest clinical efficacy.

Fifty Years of Beta-adrenergic Blockade: A Golden Era in Clinical ...

Based on the concept of a functional adrenergic receptor that mediated the effects of catecholamines, the introduction of the first beta-blocker caused a ...

Adrenergic Nervous System in Heart Failure | Circulation Research

Evolving concepts in G ... Cardiovascular pharmacogenomics of adrenergic receptor signaling: clinical implications and future directions.

β-Adrenergic Receptor Signaling and Heart Failure

Ferguson, S.S.. Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. Pharmacol Rev.

The Receptor Concept:

β-adrenergic receptors and adenylyl cyclase are separable macro-. Review. 328. Page 4. Evolving Receptor Concepts molecules. In 1976, Orly and Schramm ...

Evolution-guided discovery and recoding of allosteric pathway ...

T Huber, S Menon, TP Sakmar, Structural basis for ligand binding and specificity in adrenergic receptors: Implications for GPCR-targeted drug discovery.

The Discovery of Novel α2a Adrenergic Receptor Agonists ... - OUCI

... adrenergic receptors in hypertension and heart failure: Experimental and clinical ... Adrenergic receptors–evolving concepts and clinical implications, N. Engl. J ...

Interactions of agonists and antagonists with beta-adrenergic ...

... clinical implications. van Wieringen JP, Booij J, Shalgunov V ... Evolving concepts of partial agonism. The beta-adrenergic receptor as a paradigm.

Beta-Adrenergic Receptors - SpringerLink

The concept of an entity or substance that recognizes and discriminates on the basis of geometric properties of hormones or drugs has been evolving for more ...

Cardiac α1A-adrenergic receptors: emerging protective roles in ...

Of note, dabuzalgron was well tolerated without any blood pressure effects in multiple clinical trials for treatment of urinary incontinence (79) ...

Role of α- and β-adrenergic signaling in phenotypic targeting

... evolve, our therapeutic armamentarium for the ... Alpha 1-adrenergic receptor regulation: basic science and clinical implications.

Citations to Reduced beta 1 receptor messenger RNA abundance in ...

... adrenergic receptor pharmacology: Molecular mechanisms and clinical ... Adrenergic Receptors — Evolving Concepts and Clinical Implications

beta-blocker reverses inhibition of beta-2 adrenergic receptor ...

However, these unexpected observations may have significant clinical implications ... Evolving concepts in G protein-coupled receptor endocytosis: ...

Alpha-1-adrenergic receptors: Targets for agonist drugs to treat ...

Low α1- agonist doses have adaptive cardiac effects without changing ... The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical ...

Cardiac Alpha1-Adrenergic Receptors: Novel Aspects of Expression ...

... evolving concepts in the field, such as ligand bias, &bgr;-arrestin ... α1-Adrenergic receptor regulation: basic science and clinical implications · G ...

Adrenal adrenoceptors in heart failure: fine-tuning cardiac stimulation

10. MacMillan, L.B. ... Central hypotensive effects of the alpha2a-adrenergic receptor subtype ... Ferguson, S.S.. Evolving concepts in G protein-coupled ...

Molecular Pathways: Beta-Adrenergic Signaling in Cancer

... concept trials in clinical oncology. Clinical trial initiation ... CNS adrenergic receptors seem to play a role in some protective effects ...

Evolving insights regarding mechanisms for the inhibition of insulin ...

Clinical Implications. α2-Adrenergic receptor involvement in diabetes. Research into the various causes of type 2 diabetes has usually focused on the ...