Apoptotic stress causes mtDNA release during senescence ...

Mitochondria–cGAS–STING axis is a potential therapeutic target for ...

Many stress situations lead to senescence, including telomere shortening, genotoxic stress, oncogene- and oxidative-induced stress, and mitochondrial ...

Mitochondrial DNA Release Drives Senescence Signature - NOVOS

mtDNA Release: mtDNA leaks into the cytosol during senescence, impacting cell function and inflammation. Mitochondrial Permeabilization: This ...

Crosstalk between mitochondria–ER contact sites and the apoptotic ...

... mtDNA release during apoptosis. EMBO J ... Victorelli, et al. Apoptotic stress causes mtDNA release during senescence and drives the SASP.

Mitochondrial Quality Control Processes at the Crossroads of Cell ...

For instance, the release of mtDNA via MOMP under apoptotic stress has recently been shown to trigger senescence programs. Furthermore, pyroptosis, a caspase- ...

Cytoplasmic mtDNA clearance suppresses inflammatory immune ...

], cellular senescence [4. 4. Victorelli, S. ... Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature. 2023 ...

Mechanisms and effects of activation of innate immunity by ...

48. Victorelli. S. ,. Salmonowicz. H. ,. Chapman. J. , et al. . Apoptotic stress causes mtDNA release during senescence and drives the SASP .

Hanna Salmonowicz on LinkedIn: Apoptotic stress causes mtDNA ...

It is more of a sudden event like a "click". Senescence and oxidative stress? - okay, but are ROS really coming from mitochondria? Here, we ...

Mitochondrial inner membrane permeabilisation enables mtDNA ...

During apoptosis, pro‐apoptotic BAX and BAK are activated, causing mitochondrial outer membrane permeabilisation (MOMP), caspase activation and cell death.

Increase in mitochondrial mass in human fibroblasts under oxidative ...

Apoptotic stress causes mtDNA release during senescence and drives the SASP. Article Open access 11 October 2023. Mitophagy plays a central role in ...

Mitochondrial DNA released by senescent cells triggers ... - bioRxiv

In line with these findings, oxidative stress induced by low dosage H2O2 was sufficient to cause the cytosolic mtDNA release in WT MEFs and ...

Browse by Research Project Code - Enlighten Publications

Victorelli, S. et al. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622(7983), pp. 627-636.

Mitochondrial DNA Leakage and cGas/STING Pathway in Microglia

106. Victorelli, S. ∙ Salmonowicz, H. ∙ Chapman, J. ... Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature. 2023; 622:627 ...

Health, Aging, and Zombie Cells – Mayo Clinic Sheds New Light on ...

“Apoptotic stress causes mtDNA release during senescence and drives the SASP” by Stella Victorelli, Hanna Salmonowicz, James Chapman, Helene ...

‪Laura Greaves‬ - ‪Google Scholar‬

2009. Apoptotic stress causes mtDNA release during senescence and drives the SASP ... mtDNA mutations causing mitochondrial disease. JHK Kauppila, HL Baines ...

Mitochondria-Targeted Catalase Does Not Suppress Development ...

Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. ... Apoptotic stress causes mtDNA release during senescence and drives the SASP.

A Boolean model of mitochondrial dynamics and cell cycle control

In contrast, during damaged-induced senescence hyperfused mitochondria ... Victorelli, et al. Apoptotic stress causes mtDNA release during senescence and drives ...

ProteomeXchange Dataset PXD040018

... Apoptotic stress causes mtDNA release during senescence and drives the SASP. ... submitter keyword: mtDNA,cellular senescence, bax, mitochondria. Contact ...

Achilles' spear: A new therapeutic target for age‐related diseases

Normally, MOMP leads to the release of mtDNA into the cytoplasm during apoptosis, but the inflammatory repercussions of this process are ...

Cytoplasmic mtDNA clearance suppresses inflammatory immune ...

Victorelli, Apoptotic stress causes mtDNA release during senescence and ... Riley, Mitochondrial inner membrane permeabilisation enables mtDNA release during ...

Mechanism and therapeutic potential of targeting cGAS-STING ...

Mitochondrial oxidative stress leads to release of oxidized mtDNA ... Apoptotic stress causes mtDNA release during senescence and drives the SASP.