CNSC|27. INTRATUMORAL CANCER CELL NETWORKS IN BRAIN ...

Local and distant response to intratumoral immunotherapy assessed ...

Methods CT26 and MC38 syngeneic colorectal tumor cells were implanted subcutaneously on both flanks of Balb/c and C57Bl/6 mice, respectively. Hamster anti-mouse ...

New Molecular Strategies to Cure Brain Tumors - JAMA Network

Therapy of malignant brain tumors by intratumoral implantation of retrovirus-producing cells. ... 27. Elledge S Cell cycle checkpoints: preventing an ...

Regional and intratumoral adoptive T-cell therapy

Adoptive T-cell therapies (ACTs) including tumor-infiltrating lymphocytes and engineered T cells (transgenic T-cell receptor and chimeric ...

Biologically-informed deep neural networks provide quantitative ...

Intratumoral heterogeneity poses a significant challenge to the diagnosis and treatment of glioblastoma (GBM). This heterogeneity is further ...

In vivo dendritic cell reprogramming for cancer immunotherapy

However, tumor cells often do not activate T cells due to down-regulation of antigen presentation pathways, mounting an immunosuppressive tumor ...

pathways to treatment resistance and relapse in human glioblastoma

Recent studies have started to explore the scope of ITH in glioblastoma (GBM), a highly aggressive and fatal form of brain tumor, to explain its inevitable ...

Intratumoral injection of melatonin enhances tumor regression in cell ...

(C, L) Representative axial T2-weigthed images obtained by MRI of mice bearing Cal-27 or SCC-9 tumors treated with vehicle (control; after 41 days or 63 days, ...

Intratumoral Cell Heterogeneity in Patient-Derived Glioblastoma Cell ...

Glioblastoma cell lines derived from different patients are widely used in tumor biology research and drug screening. A key feature of glioblastoma is the ...

The Intratumoral Heterogeneity Reflects the Intertumoral Subtypes of ...

Glioblastoma multiforme (GBM) is the most frequent and aggressive primary brain tumor in adults. Despite extensive therapy the prognosis for ...

Emerging Systemic Treatment Perspectives on Brain Metastases

These spatial tumor microenvironment differences between primary sites and metastatic sites may explain heterogeneous response rates (RRs) to immunotherapy. T- ...

Biological intratumoral therapy for the high-grade glioma part II: vector

The basis of this therapy is that only tumor cells in the brain express appreciable levels of human leukocyte antigens, limiting the off-target effects [ ...

Brain intratumoural astatine-211 radiotherapy targeting syndecan-1 ...

Glioblastoma (GB), the most aggressive brain cancer, remains a critical clinical challenge due to its resistance to conventional treatments.

Intratumoral Injection of Large Surface Area Microparticle Taxanes ...

Increased levels of checkpoint expression of immune cells occurred in clinical trials of high-risk non-muscle-invasive bladder cancer (LSAM-DTX) ...

Intratumoral co‐injection of NK cells and NKG2A‐neutralizing ...

Because the human tumor cell lines that we analyzed weakly expressed surface HLA‐E, we transfected the squamous cell carcinoma CAL‐27 cell line, ...

Investigation of Inter- and Intratumoral Heterogeneity of ...

The analysis allowed to separately cluster normal brain and cancer sam- ... Cancer Cell 17, 98 –110. 5. Patel, A. P., Tirosh ... Cancer Genome Atlas Research ...

Abstracts Day 1

To visualise the effect of disorganization of the SNS neural network on metastatic colonisation, we transduced MDA-MB-231HM cancer cells to ...

Impact of CD4 T cells on intratumoral CD8 T-cell exhaustion and ...

Background Glioblastoma is a fatal disease despite aggressive multimodal therapy. PD-1 blockade, a therapy that reinvigorates hypofunctional exhausted CD8 T ...

Human breast cancer metastases to the brain display GABAergic ...

Despite disseminating to distant organs as malignant scouts, most tumor cells fail to remain viable after their arrival. The physiologic microenvironment of the ...

mRNA lipid nanoparticles for next-generation oral cancer tumour ...

... intratumoral administration in a CAL-27 xenograft model. E10i-494 ... tumour-suppress-mediated toxicity was evaluated in CAL-27 cells.

CAR T cells: engineered immune cells to treat brain cancers and ...

Brain tumor, in general, is a mass/growth of abnormal brain cells. Malignant brain tumors can either originate primarily in the brain or as ...