Canalizing kernel for cell fate determination

Characterization of cell-fate decision landscapes by estimating ...

Modulation of gene expression during differentiation by transcription factors promotes cell diversity. Despite their role in cell fate ...

Modeling signaling-dependent pluripotency with Boolean logic to ...

Pluripotent stem cells (PSCs) exist in multiple stable states, each with specific cellular properties and molecular signatures. The mechanisms that maintain ...

Regulators of early maize leaf development inferred from ... - PNAS

To identify the regulators, we obtained the transcriptomes of 11 maize embryonic leaf cell types from five stages of pre-Kranz cells starting ...

Global Stabilization of Boolean Networks to Control the ... - Frontiers

... cell fate determination (Grieco et al., 2013). A comparative study with feedback vertex set control, the control kernel method, and the stable motif control ...

The phenotype control kernel of a biomolecular regulatory network

Controlling complex molecular regulatory networks is getting a growing attention as it can provide a systematic way of driving any cellular ...

Maize sex determination and abaxial leaf fates are canalized by a ...

MicroRNAs (miRNAs) represent another class of small non-coding RNA produced using similar cellular machinery, but these appear to act primarily ...

Canalizing cell fate by transcriptional repression - OUCI

This modulation effectively suppresses master regulators of alternative fate programs and their downstream targets. The modularity and dynamic behavior of these ...

Canalizing cell fate by transcriptional repression - CoLab

Precision in the establishment and maintenance of cellular identities is crucial for the development of multicellular organisms and requires ...