Contribution of Humanized Liver Chimeric Mice to the Study of ...

Citations to Human liver chimeric mice provide a model for hepatitis ...

Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment ... Citation Information: J Clin Invest. 2010;120(3):924-930. https ...

Chimeric Mouse Models: Human and Mouse Interactions

Humanized liver mouse models are increasingly being used in preclinical trials and have allowed for groundbreaking in-vivo research to evaluate everything ...

[Contribution of chimeric mice with a humanized liver ... - BioSeek.eu

... human hepatocytes; these mice have been used as prediction models. Studies performed thus far indicate that chimeric mice with a humanized liver can be used ...

Generation of Novel Chimeric Mice with Humanized Livers by Using ...

These results indicate that hemizygous cDNA-uPA/SCID mice may be novel and useful hosts for producing chimeric mice for use in future long-term studies.

Chimeric Mouse With Humanized Liver Is an Appropriate Animal ...

In the present study, we provide novel information on the utility of chimeric mice with humanized liver (PXB mice) to evaluate the key events of ...

Human hepatocyte PNPLA3-148M exacerbates rapid non-alcoholic ...

Here, we study how human hepatocytes with PNPLA3 148I and 148M variants engrafted in the livers of broadly immunodeficient chimeric mice respond ...

Application of Chimeric Mice with Humanized Liver for Study of ...

Application of chimeric mice with humanized liver for study of human-specific drug metabolism. Thomas J Bateman, Drug Metab Dispos, 2014.

Contribution of Humanized Liver Chimeric Mice to the Study of ... - BVS

Contribution of Humanized Liver Chimeric Mice to the Study of Human Hepatic Drug Transporters: State of the Art and Perspectives.

Characterization and applications of chimeric mice with humanized ...

Chimeric mice with humanized livers and human hepatocytes isolated from these mice have immense po- tential in future applications, such as for studies on effi-.

Chimeric Mice with Hepatocyte-humanized Liver as an Appropriate ...

However, the contribution of h-hepatocytes (heps) to the species-specificity remains to be clarified. In this study, the effects of fenofibrate were ...

Utility of Chimeric Mice with Humanized Liver for Predicting Human ...

The livers of these mice are repopulated mostly with human hepatocytes and express human drug-metabolizing enzymes and drug transporters, suggesting that these ...

A Unique Tool for in Vivo and in Vitro Enzyme Induction Studies

To generate chimeric mice with humanized livers, cryopreserved human hepatocytes, which had been donated with informed consent, were purchased from BD ...

Insights From Liver‐Humanized Mice on Cholesterol Lipoprotein ...

Liver‐humanized mice (LHM) are considered a promising model to study human hepatic and systemic metabolism. Therefore, we aimed to further explore their ...

Chimeric Mice With Humanized Livers Demonstrate Human-Specific ...

Chimeric mice with humanized liver (hereafter referred as chimeric mice) may be useful tools for evaluating such human-specific hepatotoxicity ...

Contribution of Humanized Liver Chimeric Mice to the Study of ...

Contribution of Humanized Liver Chimeric Mice to the Study of Human Hepatic Drug Transporters: State of the Art and Perspectives.

Humanized Liver Mouse Models for Translational Preclinical Research

PXB-mice have up to 95% human hepatocyte engraftment in the liver, and express stable blood levels of human albumin, a biomarker of humanization, over their ...

Humanized chimeric mouse models of hepatitis B virus infection

Research efforts should be directed towards creating mouse models harbouring human hepatocytes stably integrated in the liver parenchyma. Alb-uPA/SCID chimeric ...

Mice with Artificial Human Liver - aasld

Such chimeric mice have been used to study human drug metabolism and infections by hepatitis viruses and parasites.7-11 There are, however, some drawbacks, in ...

Mice with 'humanized' livers improve early drug testing, scientist show

The chimeric mice used in the new study varied in the extent to which their livers were composed of human cells. Their overall metabolic ...

Using Chimeric Mice with Humanized Livers to Predict ... - AVESİS

The differences in the rodent and human pathways for clemizole metabolism were of importance, because the predominant human metabolite was found to have ...