Corticobulbar and cerebellar components in primary lateral sclerosis

Progressive Cerebrocerebellar Uncoupling in Sporadic and Genetic ...

Amyotrophic lateral sclerosis (ALS) is traditionally associated with relentless degenerative changes in the primary motor cortex, corticospinal ...

Cerebellar degeneration in primary lateral sclerosis - ResearchGate

Sporadic reports have indicated that in addition to the motor cortex and corticospinal tracts, the cerebellum may also be affected in PLS. Cerebellar ...

Does primary lateral sclerosis exist? | Brain - Oxford Academic

PLS has been defined as a rare, non-hereditary disease characterized by progressive spinobulbar spasticity, related to the selective loss of precentral ...

Resting state fMRI analysis of pseudobulbar affect in Amyotrophic ...

We aimed at exploring brain functional connectivity (FC) correlates of PBA in patients with amyotrophic lateral sclerosis (ALS), the most common motor neuron ...

Resting state fMRI analysis of pseudobulbar affect in Amyotrophic ...

Our findings suggest that some alterations of fronto-tempo-parietal-cerebellar circuits could be related to PBA in ALS. In particular, the ...

Clinical and neuroimaging characteristics of primary lateral sclerosis ...

We hypothesized that regional differences in motor cortex, CST, and brainstem–cerebellar pathways would be able to differentiate PLS-PSP from ...

Primary Lateral Sclerosis | 5-Minute Clinical Consult

Primary lateral sclerosis (PLS) is a rare progressive degenerative disease of the corticospinal and corticobulbar tracts (upper motor neurons [UMNs]), ...

JNS Vol 451 | August 2023 - World Federation of Neurology

Radiological correlates of pseudobulbar affect: Corticobulbar and cerebellar components in primary lateral sclerosis · Published online: June 30, ...

HSP & PLS - Spastic Paraplegia Foundation

It is often referred to as a benign variant of Amyotrophic Lateral Sclerosis (ALS, Lou Gehrig's disease). The primary difference between the two is that in PLS ...

Pathology of Motor Neuron Disorders - Medscape Reference

Because of the loss of muscle bulk through atrophy, rigor mortis is usually absent in advanced stages of ALS disease. Primary lateral sclerosis.

Mimics and chameleons in motor neurone disease

Corticobasal degeneration is an extremely rare extra-pyramidal rather than UMN neurodegenerative disorder, but is occasionally mislabelled as primary lateral ...

August 15, 2023 - Journal of the Neurological Sciences

Radiological correlates of pseudobulbar affect: Corticobulbar and cerebellar components in primary lateral sclerosis. Marlene Tahedl,; Ee Ling Tan,; We Fong ...

Corticonuclear and corticospinal tracts - Kenhub

This tract originates from upper motor neurons (UMN) located in the lateral aspect of the primary motor cortex. Specifically, this tract originates from the ...

Amyotrophic Lateral Sclerosis (ALS) Anatomical Involvement - AAET

Upper Motor Neurons. The upper motor neurons are derived from corticospinal and corticobulbar fibers that originate in the brain's primary motor cortex. They ...

Upper Motor Neuron Disorders: Primary Lateral Sclerosis ... - MDPI

The focal atrophy of the precentral gyrus is typically greater than that found in ALS and is felt to be secondary to the duration of the disease ...

Disorders of the Motor System (Section 3, Chapter 6) Neuroscience ...

In the initial stages after damage to motor cortex, the contralateral side of the body shows a flaccid paralysis. Gradually, over the course of a few weeks, ...

Corticobulbar tract involvement in amyotrophic lateral sclerosis

Summary. We investigated corticobulbar tract function by recording from the tongue and orofacial muscles and using transcranial magnetic stimulation (TMS) ...

Motor Neuron Susceptibility in ALS/FTD - Frontiers

In particular, primary lateral sclerosis (PLS) affects UMNs but it progresses much slowly than ALS. It also has a significantly lower mortality rate (Tartaglia ...

Pyramidal tracts - Wikipedia

The corticospinal fibers converge to a point when descending from the internal capsule to the brain stem from multiple directions, giving the impression of an ...

Progressive Cerebrocerebellar Uncoupling in Sporadic and Genetic ...

The contribution of cerebellar disease burden to dysarthria, dysphagia, gait impairment, pseudobulbar affect, and cognitive deficits should ...