Eph receptor signaling complexes in the plasma membrane

(PDF) Eph Receptor Signaling and Ephrins - ResearchGate

Additionally, Eph receptors can modulate cell behavior independently of ephrin binding and kinase activity. The Eph/ephrin system regulates many ...

Eph Receptor | SpringerLink

The membrane attachment of ephrins is believed to be essential for mediating the cell contact-dependent functions of the Eph receptors (see below), although ...

Eph-ephrin signaling modulated by polymerization and ... - PNAS

Eph receptor signaling plays key roles in vertebrate tissue boundary formation, axonal pathfinding, and stem cell regeneration by steering cells ...

Epha1 - Ephrin type-A receptor 1 - Mus musculus (Mouse) | UniProtKB

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin ... cell surface receptor signaling pathway. Source:UniProtKB. Biological Process ...

Architecture of Eph receptor clusters - Scite

Abstract: Eph receptor tyrosine kinases and their ephrin ligands regulate cell navigation during normal and oncogenic development. Signaling of Ephs is ...

Spatial control of membrane receptor function using ligand ...

Stein, E. et al. Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses. Genes ...

Eph Receptors, Ephrins, and Synaptic Function - Sage Journals

The cell surface localization of both the Eph receptors and the ephrins enables these proteins to signal bidirectionally at sites of cell-to-cell contact, such ...

Eph receptor signaling in C. elegans - WormBook

Eph receptors are expressed in almost every cell type in the human body, yet their roles in development, physiology, and disease are ...

[PDF] EphB/ephrinB Signaling in Cell Adhesion and Migration

54 Citations · Eph/ephrin signalling serves a bidirectional role in lipopolysaccharide-induced intestinal injury · Cargo binding promotes KDEL receptor clustering ...

Role of SHIP2 in cell repulsion regulated by Eph receptor ... - bioRxiv

Eph receptor tyrosine kinases comprise a large family of receptors which mediate cell contact dependent signaling upon interacting with membrane ...

The EphA2 Receptor and EphrinA1 Ligand in Solid Tumors

Other Eph/ephrin interfaces are responsible for mediating the higher-order clustering of Eph-ephrin dimeric complexes thought to occur during ...

Regulation of cell differentiation by Eph receptor and ephrin signaling

(B) Borders and boundary cells in the vertebrate hindbrain. Complementary expression of Eph receptors and ephrins underlies both the segregation of cells which ...

Recruitment of Eph receptors into signaling clusters does not require ...

Eph receptors and their cell membrane-bound ephrin ligands regulate cell positioning and thereby establish or stabilize patterns of cellular organization.

Eph Receptors and Ephrin Signaling Pathways: A Role in Bone ...

EphrinA ligands are attached to the extracellular cell membrane with a glycosylphosphatidylinositol (GPI) anchor. In contrast, ephrinB ligands are transmembrane ...

Eph/ephrin family anchored on exosome facilitate communications ...

Interactions of Ephrins and Eph receptors at cell membranes play crucial role in boundary formation and axon guidance.

Targeting EphA2 in cancer | Journal of Hematology & Oncology

Eph receptors and the corresponding Eph receptor-interacting (ephrin) ligands jointly constitute a critical cell signaling network that has ...

Eph Receptors in Cancer - MDPI

(A) Interaction of Eph receptor and ephrin on neighbouring cells causes clustering of Eph–ephrin complexes and the beginning of canonical signalling. The ...

Specific Eph receptor-cytoplasmic effector signaling mediated by ...

Therefore, the cytoplasmic domains of Eph receptors must be able to engage different intracellular effectors in response to ephrin ligands. How ...

Ephrin A Signaling - GeneGlobe - QIAGEN

The EphrinA ligands (A1-A6) are tethered to the plasma membrane by a GPI anchor and preferentially bind EphA (1-10) receptors. The EphrinB ligands (B1-B3), ...

Roles of Eph/ephrin bidirectional signaling in central nervous ...

Eph receptors are activated when bound to membrane-combined ephrin ligands. A total of nine EphA receptors preferentially bind to five ...