Essential Functional Interactions of SAGA

Architecture of the multi‐functional SAGA complex and ... - FEBS Press

The general transcription factor TFIIA plays a crucial role in unlocking TBP and releasing DNA binding inhibition. When the SAGA-TBP complex is ...

The biochemical and genetic discovery of the SAGA complex.

Importantly, the discovery of SAGA clarified years of genetic and biochemical studies on transcriptional regulation by showing that Gcn5 exists ...

SAGA Complex - The Nogales Lab

SAGA has been functionally implicated in a multitude of cellular pathways, from serving as a regulatory hub in transcription to its involvement in cell ...

The SAGA complex, together with transcription factors and the ...

The main finding of this study is that the SAGA complex plays a crucial role in carrying out a wide range of specific changes in the ...

The SAGA acetyltransferase module is required for the maintenance ...

We additionally demonstrate that the SANT domain of ADA2B is required for ADA2B protein stability and for interaction with GCN5 and PCAF, ...

Pseudokinase Domain of Saccharomyces cerevisiae Tra1 Is ...

Abstract. Tra1 is an essential component of the SAGA/SLIK and NuA4 complexes in S. cerevisiae, recruiting these co-activator complexes to specific promoter.

Two roles for the yeast transcription coactivator SAGA and a set of ...

We find that SAGA has two separable functions in gene expression: (1) a general function important for transcription of nearly all genes.

Molecular Architecture of the S. cerevisiae SAGA Complex

interactions within SAGA. Two Taf subunits in SAGA, lecular ... Essential functional interac- tions of SAGA, a Saccharomyces ...

Conservation and diversity of the eukaryotic SAGA coactivator ...

The evolutionary conservation of SAGA highlights its indispensable role in eukaryotic life, thus deciphering the mechanisms of action of SAGA is ...

Multiple intermolecular interactions facilitate rapid evolution of ...

Essential genes are commonly assumed to function in basic cellular processes and to change slowly. However, it remains unclear whether all ...

The SAGA complex regulates early steps in transcription via its ...

The SAGA coactivator complex is essential for eukaryotic transcription and comprises four distinct modules, one of which contains the ubiquitin hydrolase ...

SAGA Complex Subunits in Candida albicans Differentially ...

SAGA (Spt-Ada-Gcn5-acetyltransferase) is a highly conserved, multiprotein co-activator complex that consists of five distinct modules.

SAGA and SAGA-like SLIK transcriptional coactivators are ... - OUCI

... SAGA (Spt/Ada) complex, Genes Dev., № 11, с. 1640 https://doi.org/10.1101/gad.11.13.1640; Roberts, Essential functional interactions of SAGA, a Saccharomyces ...

Polyglutamine-expanded spinocerebellar ataxia-7 protein disrupts ...

Our findings indicate that yeast Sca7 is necessary for the integrity and function of both SAGA and SLIK, and that the human ataxin-7 is able to compliment the ...

TRA1 - Transcription-associated protein 1 | UniProtKB | UniProt

Essential for vegetative growth. Functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and SLIK. SAGA is ...

SAGA factor-like TAF6 - Society for Developmental Biology

In addition to its enzymatic activities, SAGA has transcription coactivator activities mediated through its interactions with transcription ...

The SAGA core module is critical during Drosophila oogenesis and ...

This study shows that the non-enzymatic core module of SAGA is required for Drosophila oogenesis, while the enzymatic functions are largely dispensable.

The SAGA chromatin-modifying complex: the sum of its parts is ...

The SAGA complex incorporates subunits that are important for mRNA splicing. These are associated with the U2 small nuclear ribonucleoprotein particle (U2 snRNP) ...

Targeting the SAGA and ATAC Transcriptional Coactivator ...

Both SAGA and ATAC function as transcriptional coactivators. These complexes are targeted to genomic loci through interactions with sequence-specific ...

Plc1p Is Required for SAGA Recruitment and Derepression of Sko1p ...

Essential functional interactions of SAGA, a Saccharomyces cerevisiae complex of Spt, Ada, and Gcn5 proteins, with the Snf/Swi and Srb/mediator complexes ...