Genetics of cancer therapy|induced cardiomyopathy

Development of anthracycline-induced dilated cardiomyopathy due ...

As shown in our case, for cancer patients bearing the mutation highlighted in LMNA gene, treatment with anthracyclines can be considered a risk ...

Genetics of cancer therapy-associated cardiotoxicity - ResearchGate

Pathogenic variants in the genes encoding proteins that comprise sarcomeres also contribute to cardiomyopathy following cancer therapies. Furthermore, genetic ...

Genetic Variants Associated With Cancer Therapy-Induced ...

ConclusionsUnrecognized rare variants in cardiomyopathy-associated genes, particularly TTNtvs, increased the risk for CCM in children and adults, and adverse ...

Genetics of cancer therapy-associated cardiotoxicity - OUCI

List of references · Ghideon, Risk prediction model for heart failure and cardiomyopathy after adjuvant trastuzumab therapy for breast cancer, J. Am. Heart Assoc ...

(PDF) Genetic Variants Associated With Cancer Therapy-Induced ...

Background: Cancer therapy-induced cardiomyopathy (CCM) is associated with cumulative drug exposures and preexisting cardiovascular ...

Heart damage from cancer drugs linked to faulty genes

The research team found patients who developed the heart condition were more likely to carry genetic faults linked to cardiomyopathy. In ...

Cancer Treatment-Induced Cardiomyopathy Linked to Rare Variants

If cancer patients carrying the variants could be identified early, their therapeutic strategy could be altered to reduce their risk of ...

Genetic Variants Associated With Cancer Therapy–Induced ... - OUCI

Background: Cancer therapy–induced cardiomyopathy (CCM) is associated with cumulative drug exposures and preexisting cardiovascular disorders.

Genetic Variants Associated With Cancer Therapy–Induced ...

BACKGROUND:Cancer therapy–induced cardiomyopathy (CCM) is associated with cumulative drug exposures and preexisting cardiovascular disorders.

Genetic Predisposing Variants Associated with Cancer Therapy ...

Interpretation: Rare variants in cardiomyopathy-associated genes, particularly TTNtv, increase the risk for CCM in children and adults, and ...

Genetic Variants Associated With Cancer Therapy–Induced ...

BACKGROUND:Cancer therapy–induced cardiomyopathy (CCM) is associated with cumulative drug exposures and preexisting cardiovascular disorders.

Unravelling the mystery of heart failure after cancer survival

They identified that many of the patients who had developed heart failure after chemotherapy carried variants of the cardiomyopathy genes that ...

Genetic Crosstalk in Cancer-Therapy-Induced Cardiomyopathy

A genetic study links cancer-therapy-induced and dilated cardiomyopathies and signals how identification of genetic risk factors may help ...

Genetic variants could be key to identifying chemo-induced ...

“Existing evidence supports the hypothesis that genetic variation contributes to chemotherapy-related cardiac dysfunction,” Linschoten and ...

Cardiac Toxicities in the Era of Precision Medicine: Underlying Risk ...

Similarly, in the Children's Oncology Group, the young seem particularly at risk for cardiac toxicity; childhood cancer survivors are at a 15-fold higher risk ...

A Role for Genetics in Racial Disparities of Therapy-Related ...

The noteworthy findings include a disproportionate risk of cardiomyopathy among African-American childhood cancer survivors and the ...

Transcriptome-wide association study uncovers the role of essential ...

Examination of cardiotoxic/cardioprotective gene sets revealed an enrichment of genes whose expression is (1) decreased upon treatment of HCM ...

Uncovering the Genetic Etiology of the (Posttherapy) Broken Heart

Furthermore, echocardiography was used to evaluate cardiac dysfunction in all SJLIFE survivors (8), and high-quality detailed childhood cancer treatment data ...

Common genetic predisposition for heart failure and cancer | Herz

In this regard, genetic variants classically associated with cardiomyopathies increase the risk for toxic side effects on the cardiovascular ...

Variants in structural cardiac genes in patients with cancer therapy ...

Conclusions In this case-control study, cancer patients with anthracycline-induced CTRCD have an increased burden of genetic variants in ...