Genomic Profiling of Adult and Pediatric B|cell Acute Lymphoblastic ...

Genomics and precision medicine in pediatric acute lymphoblastic ...

T-cell ALL (T-ALL) represents 15% of pediatric ALL and up to 25% of adult ALL. Its prognosis is historically considered inferior to that of B-ALL and remains a ...

Clinical, Cytogenetic & Genomic Profiling of B-Other ... - YouTube

Clinical, Cytogenetic and Genomic Profiling of B-Other Acute Lymphoblastic Leukemia: An Indian Cohort study (Abstract 2) Dhanlaxmi Shetty ...

Genetic Profiling in Children With Acute Lymphoblastic Leukemia ...

Genome expression of patients with ALL in remission referred to HSCT revealed deep immunosuppression of both B-cell and T-cell lineages, which may increase the ...

Transcriptome-wide subtyping of pediatric and adult T cell acute ...

... profiles in T-ALL and other leukemia. 8. Y. F. Liu et al., Genomic profiling of adult and pediatric B-cell acute lymphoblastic leukemia.

Genetic variants and clinical significance of pediatric acute ...

MLLr and TP53 mutations are powerful predictors for adverse outcome in pediatric B-ALL and ALL. Genetic profiling can contribute to the improvement of ...

Genetic Profiling of Pediatric Patients with B-Cell Precursor Acute ...

B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is a heterogeneous leukemia subgroup. It has multiple sub-types that are likely to be classified by ...

[PDF] Molecular genetics of B-precursor acute lymphoblastic leukemia.

A review of genome-wide genetic profiling studies on B-ALL provides new insights into clinical implication of the genetic aberrations in regard to targeted ...

Novel fusion genes driving B-cell acute lymphoblastic leukemia

-N. ∙ et al. Genomic profiling of adult and pediatric B-cell acute lymphoblastic leukemia. EBioMedicine. 2016; 8:173-183.

The genomic landscape of pediatric and young adult T-lineage ...

Genetic alterations that activate NOTCH1 signaling and T cell transcription factors, coupled with inactivation of the INK4/ARF tumor suppressors, are hallmarks ...

Childhood B-acute lymphoblastic leukemia: a genetic update

ALL is a malignant clonal proliferation of lymphoid progenitor cells, most commonly of the B-cell lineage (B-ALL). In the pediatric population, ...

Genetic Biomarkers and Their Clinical Implications in B-Cell Acute ...

... B.-S.; Zhang, M.; Jiang, L.; Li, J.-F.; Wang, M.-J.; Dai, Y.-J.; et al. Genomic Profiling of Adult and Pediatric B-Cell Acute Lymphoblastic Leukemia.

Genomic landscape of B-other acute lymphoblastic leukemia in an ...

Genomic profiling of adult and pediatric B-cell acute lymphoblastic leukemia. ... pediatric and adult acute lymphoblastic leukemia: a meta-analysis. JAMA ...

Transcriptional landscape of B cell precursor acute lymphoblastic ...

YF Liu, et al., Genomic profiling of adult and pediatric B-cell acute lymphoblastic leukemia. EBioMedicine 8, 173–183 (2016). Crossref.

Acute lymphoblastic leukaemia - The Lancet

Liu, YF ∙ Wang, BY ∙ Zhang, WN ∙ et al. Genomic profiling of adult and pediatric B-cell acute lymphoblastic leukemia. EBioMedicine. 2016; 8:173-183. Full ...

Acute Lymphoblastic Leukemia (ALL)

... pediatric and adult B-ALL have different molecular profiles. About 25 percent of adults and about 3 percent of children have an ALL subtype called “Ph ...

New Strategies in Acute Lymphoblastic Leukemia - AACR Journals

Several centers in the United States and Europe have performed genomic profiling of B-progenitor ALL and iden- tified novel genetic alterations ...

Early T-cell precursor acute lymphoblastic leukemia - Frontiers

Although ETP-ALL is derived from multipotent bone marrow progenitor cells, the genetic characteristics of pediatric and adult ETP vary. Even within the WHO ...

The evolution of relapse of adult T cell acute lymphoblastic leukemia

However, the mutational profiles of pediatric and adult malignancies exhibit discernible, albeit slight differences (Fig. 1b, bottom). The same ...

The many genomic roads to acute lymphoblastic leukemia - YouTube

Charles Mullighan - 2020 CGC Annual Meeting. The Cancer Genomics Consortium (CGC - https://cancergenomics.org/) represents a dedicated group ...

Acute lymphoblastic leukemia: a genomic perspective - Elsevier

... pediatric acute lymphoblastic leukemia by gene expression profiling. ... 2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and ...