Germline cis variant determines epigenetic regulation of the anti ...

Genetic Determinants of Epigenetic Patterns: Providing Insight into ...

Three recent studies point to an important role of genetic variants in determining histone modification patterns (23–25). ... Such cis-acting ...

[PDF] Germline cis variant determines epigenetic regulation of the ...

Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD). Ting Zhang, Alisa ...

Epigenetics - Wikipedia

In biology, epigenetics is the study of heritable traits, or a stable change of cell function, that happen without changes to the DNA sequence.

Epigenetics and phenotypic variation in mammals - SpringerLink

... determined phenotypic variation in suitable animal models. Similar content ... epigenetic regulation of genes are at heart a genetic cause of variation.

lenti-EF1a-dCas9-KRAB-Puro Citations (10) - Addgene

Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD). Zhang T, Ambrodji A, ...

Epigenetic Regulation in Hydra: Conserved and Divergent Roles

The most common universal variants of H3 are CenH3 and H3.3 which have roles in assembling the kinetochore, transcriptional regulation, and germ-line specific ...

Epigenetic regulation of cell state by H2AFY governs ... - JCI

H2AFY sustains the adrenergic cell status of NB cells. H2AFY is a core histone variant that can replace the replication-coupled H2A histone in ...

Epigenetic regulation of female germline development through ...

Several epigenetic pathways, such as small RNA pathway, DNA methylation, histone modification, and histone variants, are involved in the second ...

Genetic and epigenetic regulation of human aging and longevity

In very old age (> 90 years) specific longevity genes emerge from the shadows and dominate over environmental influences in lifespan determination. Recent data ...

Steven M Offer | Department of Pathology - Carver College of Medicine

Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD). bioRxiv. [Preprint] ...

Variation in DNA Methylation in Avian Nestlings Is Largely ...

Epigenetic modifications are mechanisms that regulate gene expression without changing the primary nucleotide sequence (Richards 2006), and they ...

Mechanisms of epigenetic inheritance of variable traits through the ...

... germline. Epialleles: Refers to heritable alternative expression states of a gene that are not caused by genetic variation. Epialleles can often switch ...

Epigenetic mechanisms regulating T-cell responses

Fig 1 Epigenetic mechanisms, including DNA methylation, histone modification, and chromatin structure and their role in gene regulation. A, DNA methylation in ...

Epigenetic Regulation of Vascular Endothelial Gene Expression

First, DNA methylation itself can impede the binding of transcription factors to CpG dinucleotide-containing cis-DNA binding elements. Methyl ...

Sperm-inherited H3K27me3 epialleles are transmitted ... - PNAS

... germline tissues, and tissue context determined which genes were up-regulated. ... regulate, and so are referred to as cis epigenetic regulators.

Systemic interindividual epigenetic variation in humans is ...

Genetic variants that correlate with methylation at a specific CpG site (usually in cis) are known as methylation quantitative trait loci (mQTL) ...

The Role of Parental and Grandparental Epigenetic Alterations in ...

... genetic variants that interact to influence ... It remains to be seen if true germline transmission of epimutations occurs or whether cis ...

Genetic, epigenetic and genomic effects on variation of gene ...

Although the importance of the role of cis-acting regulatory variation in determining gene expression variation confirms previous observations ...

Epigenetic Mechanisms Governing Female and Male Germline ...

Finally, we reflect on how the sex-specific epigenetic landscapes observed in the mouse germline impact transcriptional regulation in both the ...

Epigenetic regulation of human placental function and pregnancy ...

Epigenetic variation in the placenta is now emerging as a candidate mediator of environmental influence on placental functioning and a key regulator of ...