Increased TGF|b2 in severe asthma with eosinophilia

Increased TGF-β2 in severe asthma with eosinophilia - Scite

Recently, BALZAR et al [174] reported that there were more TGF-b 2 positive cells in endobronchial tissue biopsies from eosinophilic severe asthmatics.

Eosinophils and T2 inflammation in severe asthma

It is accompanied by elevated blood eosinophil count and elevated fractional exhaled nitric oxide (FeNO) which are the main biomarkers used in order to ...

Increased TGF-beta2 in severe asthma with eosinophilia - EurekaMag

0001). The increase was due to severe asthma tissue eosinophils which, unlike eosinophils in other groups, expressed high amounts of TGF-beta2. Subjects with ...

Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma

Some patients with severe asthma have frequent exacerbations associated with persistent eosinophilic inflammation despite continuous treatment ...

The Biology of Eosinophils and Their Role in Asthma - Frontiers

The phenotype of “severe eosinophilic asthma” refers to a subgroup of asthmatic patients with evidence of eosinophilia that often require high maintenance doses ...

Management of the patient with eosinophilic asthma: a new era begins

Patients with this phenotype show persistent eosinophilic airway inflammation despite treatment with inhaled corticosteroids (ICS), which is associated with ...

IL-5 antagonism reverses priming and activation of eosinophils in ...

Eosinophils are key effector cells mediating airway inflammation and exacerbation in patients with severe eosinophilic asthma.

Human eosinophils regulate human lung- and skin-derived ... - PNAS

It has been shown that eosinophils infiltrating fibrotic lesions (25, 28) and circulating eosinophils (26) express elevated levels of TGF-β1 mRNA. In addition, ...

Eosinophils and childhood asthma

For the treatment of patients with severe eosinophilic asthma, anti-interleukin-5 preparations such as mepolizumab, reslizumab, and benralizumab ...

Involvement of Transforming Growth Factor-β-Associated Kinase 1 ...

Asthmatic patients with FAO had much greater sputum TGF-β1 concentrations than those without FAO. This was independent of airway eosinophilia as ...

Eosinophilic and Noneosinophilic Asthma - CHEST Journal

Interpretation: The severe asthma eosinophilic phenotype is more prevalent than previously thought and is phenotypically distinct when defined ...

Dupilumab in Persistent Asthma with Elevated Eosinophil Levels

Moderate-to-severe asthma remains poorly treated. We evaluated the efficacy and safety of dupilumab (SAR231893/REGN668), a fully human ...

Reduction of daily maintenance inhaled corticosteroids in patients ...

Stepwise intensification of inhaled corticosteroids (ICS) is routine for severe eosinophilic asthma, despite some poor responses to high-dose ...

Osteopontin contributes to late-onset asthma phenotypes in adult ...

In patients with severe refractory asthma, OPN levels were shown to be associated with increased levels of transforming growth factor-β1 (TGF-β1) ...

Diagnosis and management of eosinophilic asthma: a US perspective

Eosinophilic asthma can be associated with increased asthma severity, atopy, late-onset disease, and steroid refractoriness. Induced sputum cell ...

Real-World Effectiveness Study of Benralizumab for Severe ...

Benralizumab reduced asthma exacerbation rates in patients with blood eosinophil counts less than 150, more than or equal to 150, 150 to less ...

Use of biomarkers to identify phenotypes and endotypes of severe ...

Increased blood eosinophil counts are a good predictor of treatment response to corticosteroids in asthma.28,29 For example, in children who require controller ...

Depemokimab late-breaking data presented at ERS show a ... - GSK

... severe asthma with type 2 inflammation characterised by raised blood eosinophil count.1 The data were presented at the European Respiratory ...

Effect of TGF-β1 on eosinophils to induce cysteinyl leukotriene E4 ...

These findings suggest that higher levels of TGF-β1 in AERD patients may contribute to LTE 4 production via enhancing LTC 4 S expression which induces ...

Human Eosinophils Induce Mucin Production in Airway Epithelial ...

Supernatant of activated eosinophils contained increased concentrations of TGF ... severe acute asthma attack. Chest. 101. : 916. 4. Ordonez, C. L., R ...