Insights on multiple pathways of programmed cell death regulated ...

Programmed cell death is the death of a cell as a result of events inside of a cell, such as apoptosis or autophagy. PCD is carried out in a biological ...

Structural Insights into Programmed Cell Death

Malfunctions in caspase activity and the apoptotic pathway play a role in cancer and neurodegenerative diseases. This study dives into the ...

Apoptosis pathway - AnyGenes

Apoptosis involves a series of tightly regulated molecular signaling pathways that guide programmed ... 2) can prevent cell death and contribute to tumor ...

Mitophagy in Cell Death Regulation: Insights into Mechanisms and ...

Furthermore, mitophagy promotes mitochondrial degradation via the lysosomal pathway, and not only eliminates damaged mitochondria but also regulates programmed ...

Modes of Regulated Cell Death in Cancer - AACR Journals

Intrinsic Apoptosis. The intrinsic (mitochondrial) pathway serves to activate apoptosis as an appropriate response to various internal traumas, such as ...

The role of the programmed cell death protein-1/programmed death ...

The role of the programmed cell death protein-1/programmed death-ligand 1 pathway, regulatory T cells and T helper 17 cells in tumor immunity: a narrative ...

The evolution of regulated cell death pathways in animals and their ...

The coevolution of host-pathogen interactions underlies many human physiological traits associated with protection from or susceptibility to infections.

Apoptosis Caspase Pathways: A Closer Look at Cellular Suicide

Regulation of Caspase Pathways. The precise regulation of apoptosis is crucial for cellular homeostasis. Various proteins regulate these ...

Cell death pathways: intricate connections and disease implications

Intrinsic apoptosis is controlled by the equilibrium of the different Bcl‐2 (B‐cell lymphoma 2) family members which can be disrupted by various ...

PANoptosis: Novel insight into regulated cell death and its potential ...

These three pathways are activated in various cell death mechanisms in response to various external and internal cues. Apoptosis is the primary ...

New insights into the roles of CHOP-induced apoptosis in ER stress

Although both the IRE-1 and ATF6 pathways can up-regulate CHOP, the PERK pathway predominates through selective up-regulation of translation of ATF4, which ...

Programmed cell death - WormBook

Figure 2. Genetic pathway of programmed cell death in C. elegans. Three phases of programmed cell death, specification, killing, and ...

Apoptosis - Promega Corporation

The mitochondrial pathway involves members of the Bcl-2 family that regulate cytochrome c release from the mitochondria. Other studies have suggested that a ...

Cell Process: Seven Assays to Detect Apoptosis

... multiple cellular events indicative of activation of the apoptotic pathway. ... Likewise, using multiple markers can provide insight into the kinetics of ...

Intrinsic apoptosis is evolutionarily divergent among metazoans

Our results support emergence of distinct intrinsic apoptotic pathways during metazoan evolution. INTRODUCTION. Apoptosis, regulated cell death ...

Nanoparticles and neurodegeneration: Insights on multiple ...

Nanoparticles and neurodegeneration: Insights on multiple pathways of programmed cell death regulated by nanoparticles. ... Currently, nanoparticles (NPs) are ...

Programmed cell death detection methods: a systematic review and ...

The process of apoptosis involving many regulatory sets of ... Cell death pathways are tightly connected, and cross regulate each other.

Human regulatory T cells undergo self-inflicted damage ... - JCI Insight

Death by a thousand cuts: granzyme pathways of programmed cell death. ... Bcl-2 functions in an antioxidant pathway to prevent apoptosis.

Insights into the Role of Defective Apoptosis in Cancer ... - IntechOpen

Activation of several pathways, such as mitogen-activated protein ... regulates cancer cell invasion and apoptosis by targeting Bcl-2 family proteins .

Insights on aspects of apoptosis in neurodegenerative disorders

Pro- apoptotic proteins set off caspases, which then regulate several cell death pathways. These proteins also enter the cellular nucleus ...