NLRP3 Inhibitors

Spotlight on Clinical NLRP3 Inflammasome Inhibitors

Several specific inflammasome inhibitors that have entered the clinic are briefly reviewed below, although clinical data from them is not always accessible.

A patent review of NLRP3 inhibitors to treat autoimmune diseases

The current review summarizes the functional facets of the NLRP3 inflammasome, its association with autoimmune diseases, and recent patents on the development ...

Inflammasome Inhibitors | Cell Culture Tested - InvivoGen

NLRP3 Inflammasome Inhibitors. MCC950. NLRP3 inflammasome inhibitor. NT-0769. NLRP3 inflammasome inhibitor. BAY 11-7082. IκB-α inhibitor - NLRP3 inflammasome ...

A Comprehensive Toolkit for NLRP3 Inflammasome Drug Discovery

With the NLRP3 NanoBRET® TE assay, target engagement of NLRP3 inhibitors can be observed using a fluorescent tracer based on the inhibitor molecule (Figure 1).

Structure, Molecular Activation, and Inhibitor-NLRP3 Interaction

Inhibition of the NLRP3 inflammasome with MCC950 in a mouse model of juvenile IAV infection was shown to improve the survival of mice ...

NLRP3 Inhibitor, Agonist, Antagonist, Activator, Degrader, Gene

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Identification of new potent NLRP3 inhibitors by multi-level in-silico ...

Nod-like receptor protein 3 (NLRP-3), is an intracellular sensor that is involved in inflammasome activation, and the aberrant expression of ...

Inhibition of NLRP3 inflammasome activation by A20 ... - PNAS

Here, we revealed that A20 notably diminishes the expression of NEK7, leveraging its role in moderating the NF-κB signaling pathway.

NLRP3 Inflammasome Inhibitor I | 98.94%(HPLC) - Selleck Chemicals

NLRP3 Inflammasome Inhibitor I, an intermediate substrate in the synthesis of glyburide which is free of the cyclohexylurea moiety involved in insulin ...

Discovery and characterization of small-molecule inhibitors of ...

Positive controls for NLRP3 inhibition with the NLRP3 inhibitor MCC950 are included in panel B. ... NLRP3 inhibitors. The six hits reduced the IL- ...

PLK1 inhibition dampens NLRP3 inflammasome–elicited response ...

Polo-like kinase 1 (PLK1) has been widely studied for its role in mitosis. Here, using both pharmacological and genetic approaches, we ...

WO2020021447A1 - Nlrp3 inflammasome inhibitors - Google Patents

The present invention relates to novel thienopyrrolotriazinacetamide compounds of Formula (I): wherein R 1 , R 2 and R 3 are defined herein, which inhibit ...

Ventus Therapeutics Presents an Overview of its NLRP3 Inhibitors at ...

Anick Auger presented an overview of the company's novel NLRP3 inhibitor programs at the Fourth Inflammasome Therapeutics Summit, held from Nov. 29 to Dec. 1 ...

Pharma Looks to Inflammasome Inhibitors as All-Around Therapies

Many major biopharmaceutical companies are developing or acquiring drugs that target the NLRP3 inflammasome, a large intracellular complex ...

NodThera's NLRP3 Inhibitor NT-0796 Reverses Neuroinflammation ...

Taken together, the findings demonstrate that NT-0796 successfully delivered anti-neuroinflammatory and anti-inflammatory changes within 7 days ...

Role of NLRP3 Inflammasome and Its Inhibitors as Emerging ...

The application of Dapansutrile (OLT1177), a NLRP3 specific inhibitor, is reported to enhance the memory as well as learning ability, normalize ...

NLRP3 Inhibitor, MCC950, 256373-96-3 Sigma-Aldrich

NLRP3 Inhibitor, MCC950; CAS Number: 256373-96-3; Synonyms: NLRP3 Inhibitor, MCC950,N-(1,2,3,5,6,7-Hexahydro- ...

Deciphering NLRP3 Inhibitors and Keeping Up with Their Recent ...

List of NLRP3 Inhibitors · Nibrozetone · Dapansutrile · IFM-2427 · Inzomelid · NuGel · VTX-2735 · ZYIL-1 · HT-6184 · IPS-07004 ...

Tranilast directly targets NLRP3 to treat inflammasome‐driven ...

Here, we show that tranilast (TR), an old anti‐allergic clinical drug, is a direct NLRP3 inhibitor. TR inhibits NLRP3 inflammasome activation in macrophages, ...

Specific inhibition of the NLRP3 inflammasome suppresses immune ...

Specific inhibition of the NLRP3 inflammasome suppresses immune overactivation and alleviates COVID-19 like pathology in mice.