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New insights into a classic aptamer


New insights into a classic aptamer: binding sites ... - CiNii Research

New insights into a classic aptamer: binding sites, cooperativity and more sensitive adenosine detection. DOI PDF 被引用文献1件. Zijie Zhang · Olatunji Oni.

Systematic bio-fabrication of aptamers and their applications in ...

The full-length aptamer candidates primarily screened by SELEX technology are typical 50–100 nucleotides in length. There is no doubt that the ...

‪Ola Oni‬ - ‪Google Scholar‬

New insights into a classic aptamer: binding sites, cooperativity and more sensitive adenosine detection. Z Zhang, O Oni, J Liu. Nucleic acids research 45 (13), ...

(A) A scheme of structure-switching signal aptamer. Binding of...

... from publication: New insights into a classic aptamer: Binding sites, cooperativity and more sensitive adenosine detection | The DNA aptamer for adenosine ...

Targeted Selection of Aptamer Complementary Elements Toward ...

useful insight into the dynamics of the adenosine AT's duplexed aptamer domain and suggest a ... New Insights into a Classic Aptamer: Binding Sites,.

Insights into the binding mode of AS1411 aptamer to nucleolin

Aptamers are oligonucleotide sequences with a length of around 20–80 bases, including short single-strand DNA (ssDNA) or RNA molecules, first ...

Insights into the G-rich VEGF-binding aptamer V7t1: when two G ...

2017: New insights into a classic aptamer: binding sites, cooperativity and more sensitive adenosine detection Nucleic Acids Research 45(13): 7593-7601.

Aptamers 2018 - Library Publishing Media

We used fluorescence spectroscopy to measure the binding affinity and provide new insights into the binding mechanism of cocaine and quinine with the cocaine- ...

‪Zijie Zhang‬ - ‪Google Scholar‬

New insights into a classic aptamer: binding sites, cooperativity and more sensitive adenosine detection. Z Zhang, O Oni, J Liu. Nucleic acids research 45 (13), ...

Aptamer - Wikipedia

They exhibit a range of affinities (KD in the pM to μM range), with variable levels of off-target binding and are sometimes classified as chemical antibodies.

New insight into the aptamer conformation and ... - RSC Publishing

We study the interaction between one aptamer and its analyte (the MnSOD protein) by the combination of surface-enhanced Raman scattering and multivariate ...

Novel nucleic acid aptamer gold (Au)-nanoparticles (AuNPs-AptHLA ...

Nucleic acid aptamers (aptamers) are single-stranded oligonucleotides that can specifically bind to proteins or other biological macromolecules obtained from a ...

Native electrospray ionization mass spectrometry reveals multiple ...

rational design of new aptamers and represents a major gap in our knowledge ... Zhang, Z.; Oni, O.; Liu, J., New insights into a classic aptamer: ...

Aptamers as an approach to targeted cancer therapy

Aptamers can act as drugs themselves, directly inhibiting tumor cells. Alternatively, they can be used in targeted drug delivery systems to ...

Design and Prediction of Aptamers Assisted by In Silico Methods

In addition, examples of machine learning and deep learning technologies used to predict the binding of targets and ligands in the development of new drugs are ...

Development of Better Aptamers: Structured Library Approaches ...

We provide a comprehensive overview of aptamer development strategies that can help facilitate their translation into real world applications.

A Customizable Aptamer Transducer Network Designed for Feed ...

New Insights into a Classic Aptamer: Binding Sites, Cooperativity and More. Sensitive Adenosine Detection. Nucleic Acids Res. 2017, 45 (13), 7593–7601. https ...

Determining Aptamer Affinity - Base Pair Biotechnologies

In addition, aptamers are unique in ... New insights into a classic aptamer: binding sites, cooperativity, and more sensitive adenosine detection.

A guide to using nucleic acid aptamers in cell based assays

Typical volumes are 50-100µl of DPBS and MgCl2 (See note 3). *Note 3: the aptamer folding conditions are specific to each new aptamer developed, ...

Structure-Guided Designing Pre-Organization in Bivalent Aptamers ...

New insights into a classic aptamer: binding sites, cooperativity and more sensitive adenosine detection. Nucleic acids research, 2017, 45 (13): 7593-7601 ...