Plasticity in cell migration modes across development

Single Living Cell “Observation-Analysis” Integrated Platform ...

Cell migration requires the interplay among diverse migration patterns. The molecular basis of distinct migration programs is undoubtedly vital ...

Plasticity of cell migration: a multiscale tuning model

countered by migrating cells are either flat 2D sheets or 3D tissue networks. Cell migration across 2D surfaces occurs dur- ing reepithelialization of ...

Collective cell migration driven by filopodia—New insights from the ...

In principle, cellular locomotion can be divided into two categories: swimming and crawling. Flagellate-powered swimming is certainly the ...

Modeling the Mechanobiology of Cancer Cell Migration Using 3D ...

These actin-rich membrane protrusions drive local degradation of ECM through the secretion of vesicles filled with proteolytic material, thus increasing the ...

An emerging role for tissue plasticity in developmental precision

Taken together, across diverse systems, the mechanical properties of cells and tissues play a vital role in ensuring robustness during morphogenesis. Summary ...

Cancer cell plasticity: from cellular, molecular, and genetic ...

Dynamic cellular transitions, particularly the change from sessile epithelial to motile mesenchymal states, are crucial for embryogenesis and ...

Single and collective cell migration: the mechanics of adhesions

Collective migration is particularly important during development and in processes such as tissue shaping and wound healing. Collective ...

Plasticity in the Macromolecular-Scale Causal Networks of Cell ...

Heterogeneous and dynamic single cell migration behaviours arise from a complex multi-scale signalling network comprising both molecular components and ...

Plasticity of tumor cell invasion: governance by growth factors and ...

In summary, by impacting the steady-state cadherin functionality in cell–cell adhesion, growth factors and cytokines control whether tumor cells migrate in ...

Plasticity of cell migration: a multiscale tuning model - Western ...

Cell migration underlies tissue formation, maintenance, and regeneration as well as pathological conditions such as cancer invasion.

Neuroblastoma plasticity during metastatic progression stems from ...

We show that NB cells adopt a panel of transcriptome states aligned on the SNPCs-to-neuroblast differentiation branch and that the primary tumor ...

Rapid cancer cell perineural invasion utilizes amoeboid migration

In Lead cells, PXN was expressed diffusely throughout the cell's cytoplasm with greater expression in Lead than Lag cells but clearly showed ...

Understanding the driving force for cell migration plasticity - OUCI

... migration mode of macrophages, Acta Biomater., № 89, с. 47 https://doi.org ... Grashoff, Measuring mechanical tension across vinculin reveals ...

One-dimensional cell motility patterns - Physical Review Link Manager

The origin of the large cell-to-cell variability (CCV), or phenotypic, population heterogeneity, observed during cell migration is not ...

Cell polarity signaling in the plasticity of cancer cell invasiveness

Mesenchymally migrating cells may re-differentiate by mesenchymal-epithelial transition (MET) and re-establish an epithelium. Alternatively, by ...

Plasticity of cell migration resulting from mechanochemical coupling

Eukaryotic cell migration is a fundamental biological process that is essential in development ... cell migration modes of Fig.2a. The. 156.

Cellular Plasticity in Cancer - AACR Journals

Introduction. The ability of cells to adopt different identities along a phenotypic spectrum is a phenomenon broadly known as cellular plasticity. Although it ...

Constriction imposed by basement membrane regulates ... - PLOS

Constriction imposed by basement membrane regulates developmental cell migration · Abstract. The basement membrane (BM) is a specialized extracellular matrix ( ...

Mechanical plasticity in collective cell migration - HAL

Collective chemotactic migration of. Xenopus and Zebrafish cephalic neural crest cells engages long-range coordination spanning across a cluster ...

Phenotypic Heterogeneity and Plasticity of Cancer Cell Migration in ...

Matrix metalloproteinases (MMPs) are well-known factors involved in priming of the extracellular matrix (ECM) via pericellular proteolysis, which allows the ...