Platelet Derived Growth Factor Receptors

Platelet-derived growth factors and receptors - Proteopedia, life in 3D

Platelet-derived growth factor receptors, PDGF-R, are cell surface tyrosine kinase receptors for members of the platelet-derived growth factors ...

RETRACTED ARTICLE: Platelet-derived growth factor receptor-α and

These results indicate that PDGFR-α/β activity is upregulated in sarcoma CSCs and promote CSC phenotypes including migration, invasion, and ...

Platelet-derived growth factor alpha and beta receptors have ...

Platelet-derived growth factor (PDGF) signalling is essential for many key cellular processes in mesenchymal cells.

Platelet-Derived Growth Factor - R&D Systems

The PDGF isoforms exist as disulfide-linked homo- and heterodimers and differentially bind homo- and heterodimer combinations of two receptor tyrosine kinases, ...

The platelet-derived growth factor receptor as a therapeutic target

Pietras K, Ostman A, Sjoquist M, et al.: Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases ...

Platelet-derived growth factor (PDGF) cross-signaling via non ...

Our results provide some of the first evidence for PDGF cross-signaling through alternative receptors in colorectal cancer and support anti-PDGF therapy.

Platelet-derived growth factor: mechanism of action and relation to ...

PDGF exerts its mitogenic action via binding to specific cell surface receptors on responsive cells (Heldin et al. 1981). The receptor is a ...

Platelet-Derived Growth Factor and Arterial Response to Injury

In the presence of ligand, the receptors form dimers on the cell surface so that α/α dimers bind all three PDGF isoforms (AA, AB, and BB), α/β ...

Role of platelet-derived growth factors in physiology and medicine

Platelet-derived growth factors (PDGFs) and their recep- tors (PDGFRs) have served as prototypes for growth fac- tor and receptor tyrosine kinase function ...

Insights Into the Role of Platelet-Derived Growth Factors - Frontiers

Platelet-derived growth factors (PDGFs) and platelet-derived growth factor receptors (PDGFRs) are important neurotrophic factors that are expressed in ...

Platelet-Derived Growth Factor Structure, function and implications ...

In these instances, tumor cell growth may be enhanced by an autocrine receptor activation. In other tumor cell types, where PDGF is produced in the absence of ...

B Monoclonal Antibody, MOR8457, Reveals Conformational ...

Platelet derived growth factor-BB (PDGF-BB) is an important mitogen and cell survival factor during development. PDGF-BB binds PDGF receptor-β to trigger ...

Structures of a platelet-derived growth factor/propeptide ... - PNAS

Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are prototypic growth factors and receptor tyrosine kinases which have ...

Platelet-derived growth factor receptor-β, carrying the activating ...

Our findings suggest that the activated PDGFR-β (D849N) in the host animal increased the total vessel area and the average vessel surface even in PDGF-negative ...

Platelet-derived growth factor (PDGF) receptors in the developing ...

Ganglion cells are labeled with antibodies to PDGF receptor only during the period of active process outgrowth. These findings suggest that PDGF is used as a ...

Blockade of Platelet-Derived Growth Factor Receptor-Beta by ...

The addition of PEG is designed to increase the plasma half-life of the molecule. The molecular weight of CDP860 is approximately 140 kd, and it ...

The platelet-derived growth factor (PDGF) family of tyrosine kinase ...

The platelet-derived growth factor (PDGF) receptor family of receptor tyrosine kinases (class III) consists of the PDGF receptors and the ...

Use of multitarget tyrosine kinase inhibitors to attenuate platelet ...

Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) play a fundamental role in the embryonic development of the lung. Aberrant PDGF ...

Receptor, Platelet-Derived Growth Factor beta

A PDGF receptor that binds specifically to the PDGF-B chain. It contains a protein-tyrosine kinase activity that is involved in SIGNAL TRANSDUCTION.

Signal Transduction by the Platelet-Derived Growth Factor Receptor

ANTONIADES, H.N., HUMAN PLATELET-DERIVED GROWTH-FACTOR (PDGF) - PURIFICATION OF PDGF-I AND PDGF-II AND SEPARATION OF THEIR REDUCED SUBUNITS, ...