Prognostic Impact of BRAF and KRAS Mutation in Patients with ...

Prognostic impact of KRAS and BRAF mutations in patients who ...

Download Citation | Prognostic impact of KRAS and BRAF mutations in patients who underwent simultaneous resection for initially resectable colorectal liver ...

Incidence and prognostic impact of KRAS and BRAF mutation in ...

Incidence and prognostic impact of KRAS and BRAF mutation in patients undergoing liver surgery for colorectal metastases. Georgios Karagkounis, Michael S ...

Original Article Prognostic impact of KRAS and BRAF mutations in ...

Approximately 25% of CRC patients will present with synchronous colorectal liver metastases. (SCRLMs) at the initial diagnosis, and 25~50% of ...

preliminary survival analysis of patients with Colorectal Cancer

Aims: prognostic impact of mutations in BRAF and KRAS genes in patients with colorectal cancer was evaluated to detect variations in ...

KRAS Codon 12 and 13 Mutations in Relation to Disease-Free ...

Prognostic impact of specific KRAS mutations in 2,478 patients with BRAF–wild-type resected stage III colon cancer. KRAS mutations in codons 12 and 13, compared ...

Prognostic value of KRAS and BRAF mutations in curatively ...

The effect of KRAS mutations on DFS and OS was limited to patients with MSS/MSI-L tumors (HR = 1.37;. 95%CI: 1.05-1.80; HR = 1.49; 95%CI: 1.10- ...

Prognostic effect of braf and kras mutations in patients with stage iii ...

046) were independently associated with worse clinical outcomes. In patients with MSI tumors, KRAS status was not prognostic, whereas BRAF V600E mutation was ...

Prognostic impact of deficient DNA mismatch repair and KRAS and ...

... KRAS and BRAF V600E mutations in patients with lymph-node-positive colon cancer ... BRAF; Biomarker; Colorectal cancer; KRAS; Microsatellite instability ...

Prognostic value of BRAF and KRAS mutation status in stage II and ...

What's new? Mutations in the BRAF and KRAS genes are widely studied in patients with colorectal carcinomas (CRC), but their prognostic impact in cancers ...

Prognostic value of specific KRAS mutations in patients with ...

KRAS mutations occurred in 172 patients (47.5%) out of the 362 analyzed. Two different prognostic groups of KRAS mutation subtypes were ...

BRAF and KRAS Mutations Influence Prognosis in Stage III Colon ...

These results indicate that KRAS and BRAF mutations have prognostic impact only in DNA mismatch repair proficient, or MSS, stage III colon cancer.

Incidence and prognostic impact of KRAS and BRAF mutation in ...

BACKGROUNDMolecular biomarkers offer the potential for refining prognostic determinants in patients undergoing ...

CMS-dependent prognostic impact of KRAS and BRAF mutations in ...

Background: The prognostic impact of KRAS and BRAFV600E mutations in primary colorectal cancer (CRC) varies with microsatellite.

The Prognostic Impact of KRAS, Its Codon and Amino Acid Specific ...

In the KRAS-MUT group, the 3-year OS and DFS were 84% versus 95% and 64% versus 89% compared with KRAS-WT patients. In a multivariate analysis, KRAS mutation ...

Effect of KRAS and BRAF Mutations on Survival of Metastatic ...

KRAS mutations are negatively associated with OS and RFS in patients who undergo complete liver resection for CRLM. A similar negative effect on OS was observed ...

Prognostic Impact of Deficient DNA Mismatch Repair and KRAS and ...

Deng G, Bell I, Crawley S, et al. BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis ...

Histology and its prognostic effect on KRAS‑mutated colorectal ...

KRAS mutation was an independent unfavorable prognostic factor for overall survival (OS) according to multivariate analysis (P=0.001), whereas ...

Prognostic Value of BRAF and KRAS Mutations in MSI and MSS ...

Conclusions: In a pooled analysis of resected stage III colon cancer patients receiving adjuvant FOLFOX, BRAF or KRAS mutations are ...

Mutation status and prognostic values of KRAS, NRAS, BRAF and ...

In a study of 450 patients with stage I to III colon cancer, for example, PIK3CA mutations predicted a poorer prognosis, but only among KRAS ...

Clinicopathologic and prognostic associations of KRAS and BRAF ...

KRAS mutation is a poor prognostic predictor in patients with lower pT classification tumors. Anti-EGFR targeted therapy could be applied to about two-thirds of ...