Proteomic discovery of chemical probes that perturb protein ...

... protein profiling, to enrich our understanding of disease-relevant proteins and to accelerate the discovery of chemical probes for these proteins. Recent ...

Ekaterina V. Vinogradova, Ph.D. - The Rockefeller University

The study revealed a remarkable number of cysteines across many proteins with human genetic links to immunological disorders that can be targeted with small ...

cysteine | Broad Institute

Proteomic discovery of chemical probes that perturb protein complexes in human cells. Lazear MR, Remsberg JR, Jaeger MG, et al. Proteomic discovery of ...

[PDF] A Chemical Proteomics Approach to Reveal Direct Protein ...

59 Citations · Proteomic discovery of chemical probes that perturb protein complexes in human cells · In situ chromatin interactomics using a chemical bait and ...

Journal Club - Center for Innovative Proteomics - Cornell University

Proteome-Wide Assessment of Protein Structural Perturbations ... “Proteomic discovery of chemical probes that perturb protein complexes in human cells” ...

“Mirror-image” molecules pave new path for cancer drug discovery

In addition to Cravatt, Remsberg, Lazear and Jaeger, authors of the study, “Proteomic discovery of chemical probes that perturb protein ...

Chemical tools to expand the ligandable proteome - bioRxiv

Proteomic discovery of chemical probes that perturb protein complexes in human cells. Mol Cell 83, 1725-1742 e1712. 10.1016/j.molcel.2023.03 ...

Mapping the Protein Interaction Landscape for Fully Functionalized ...

Fully functionalized libraries provide a technically straightforward means to achieve this objective, since probe–protein interactions can be ...

Expedited mapping of the ligandable proteome using fully ... - Nature

Chemical probes are versatile tools to interrogate the functions of proteins in biological systems and complement genetic approaches by ...

Open resources for chemical probes and their implications for future ...

Fragment-based drug discovery (FBDD) aims to extend screening to include compounds with low molecular weight and complexity. Conceptually, this ...

Tetrazine ligation for chemical proteomics

Compared to techniques in molecular biology and genetics, chemical probes provide powerful tools to perturb protein functions rapidly with ...

‪EVERT NJOMEN‬ - ‪Google Scholar‬

Proteomic discovery of chemical probes that perturb protein complexes in human cells. MR Lazear, JR Remsberg, MG Jaeger, K Rothamel, H Her, KE DeMeester ...

Chemical Proteomics–Guided Discovery of Covalent Ligands for ...

... chemical probe and drug discovery. Here, we discuss how ... Proteomic discovery of chemical probes that perturb protein complexes in human cells, Mol.

Proteomics‐Based Discovery of First‐in‐Class Chemical Probes for ...

A first-in-class programmed cell death protein 2 (PDCD2) degrader, 10 e, was developed by combination of mass spectrometry-based proteomics ...

Biomimetic Synthesis and Chemical Proteomics Reveal ... - ChemRxiv

... perturb probe labelling of lysine residues within druggable protein ... Proteomic discovery of chemical probes that perturb protein complexes in human cells.

Chemical proteomics approaches for identifying the cellular targets ...

The review focuses on probes that can be covalently linked to their target proteins (either via intrinsic chemical reactivity or via the ...

Chemical Probes and Activity-Based Protein Profiling for Cancer ...

Click reactions can be applied to activity-based probes, enzyme inhibitor profiles, and hybrid monolithic columns for proteomic analysis and protein labeling.

Developing novel chemical probes for phosphoproteomics and ...

Chemical proteomics utilizes chemical probes to perturb, target, or manipulate proteomes to understand their functions at the cellular and molecular levels.

Chu Wang - The Wang Lab

Experimentally, we furnished the 'Activity-Based Protein Profiling (ABPP)' technology pioneered by Cravatt and colleagues with new chemical probes and new ...

Alex Reed (@alexanderwr18) / X

Chemical probes are lacking for most human proteins. Covalent chemistry represents an attractive strategy for expanding the ligandability of the proteome, and ...