The 95% effective dose of dexmedetomidine to induce adequate ...

Appropriate dose of dexmedetomidine for the prevention ... - S-Space

Dexmedetomidine can be used for the prevention of emergence agitation (EA) in children. However, an inadequate dose of dexmedetomidine can induce prolonged ...

Clinical Pharmacokinetics and Pharmacodynamics of ...

The Precedex label specifies a dosing regimen consisting of a 1-µg/kg loading dose in 10 min followed by a maintenance infusion of 0.2–0.7 µg/kg ...

High dose dexmedetomidine as the sole sedative for pediatric MRI

Over time, an effective protocol utilizing high dose dexmedetomidine as the ... in an effort to induce sedation adequate to complete the scan. A failed ...

PRECEDEX® 100 micrograms/mL Concentrate for Infusion - Medsafe

dexmedetomidine was administered by intravenous infusion at doses within the recommended dose range (0.2-0.7 mcg/kg/hr). The safety and efficacy of Precedex ...

highlights of prescribing information

In clinical trials, glycopyrrolate or atropine were effective in the treatment of most episodes of PRECEDEX-induced bradycardia. However, in some patients with ...

Effects of Perioperative Dexmedetomidine Infusion in Patients ...

The initial PCA setting was a 1-mg bolus dose with a lock-out interval of 6 min. For inadequate analgesia, additional 2-mg doses of morphine were administered ...

Precedex, Igalmi - dexmedetomidine (Rx) - Medscape

... effective dose may be appropriate. butabarbital. butabarbital and dexmedetomidine both increase sedation. Use Caution/Monitor. butalbital. butalbital and ...

Determination of the ED 95 of a single bolus dose of ... - Europe PMC

The ED 95 of dexmedetomidine for adequate sedation in children with obesity was 0.75 μg kg -1 with 95% CI of 0.638-0.780 μg kg -1.

Dexmedetomidine: What's New for Pediatrics? A Narrative Review

The time to reach minimum serum concentrations required to achieve sedation (100 ng/mL) was 20 min and 10 min, respectively, with the doubling of dosage. Peak ...

Dexmedetomidine: a magic bullet on its way into palliative care—a ...

Dexmedetomidine induces sedation mimicking deep natural sleep via the locus coeruleus. Unlike other hypnotics and sedatives, these patients are ...

Determination of the Median Effective Dose of Dexmedetomidine for ...

This study demonstrates that the ED50 of intravenous dexmedetomidine infusion in the prevention of EA among geriatric patients undergoing major ...

Dexmedetomidine - an overview | ScienceDirect Topics

Intranasal dosing is 1 to 2 μg/kg administered 30 minutes before induction, producing an observer's assessment alertness/sedation scale of 2 (responds only ...

Dexmedetomidine - Korean Journal of Anesthesiology

Dexmedetomidine shows dose-dependent sedative effects. If a large enough dose is administered, dexmedetomidine produces deep sedation or ...

Dexmedetomidine: review, update, and future considerations of ...

Anxiolysis before the induction of anaesthesia is an important aspect of paediatric perioperative planning. Currently, there is a growing interest in comparing ...

The effect of dezocine on the sufentanil induced RD in SA | DDDT

Conclusion: Dezocine can improve RD induced by sufentanil in patients with spinal anesthesia combined with low-dose dexmedetomidine, and ...

Dexmedetomidine - OpenAnesthesia

An IV bolus dose of 0.5 mcg/kg immediately following induction demonstrated a significant reduction in the incidence of emergence delirium ...

Precedex (dexmedetomidine hydrochloride) injection label

atropine were effective in the treatment of most episodes of Precedex-induced bradycardia. ... parameters when Precedex was infused (after appropriate loading ...

Dosing Guidelines for Precedex®

The table on page 5 shows the frequency at which. Precedex-sedated patients undergoing MAC sedation may experience hypotension or bradycardia and the frequency.

Adequate sedation with single-dose dexmedetomidine in patients ...

The purpose of this study was to determine the 50% effective dose. (ED50) of single-dose DMT to induce adequate light sedation in elderly ...

Determination of the 95% effective dose of remimazolam tosylate in ...

The present study aimed to determine the 95% effective dose (ED 95 ) of remimazolam tosylate in anesthesia induction to inhibit endotracheal intubation-related ...