The MENDEL|2 Randomized

Design Issues of Randomized Phase II Trials and a Proposal for ...

We present our own explorations into the possibilities of developing “phase II screening trials,” in which preliminary and nondefinitive randomized comparisons ...

Phase 2, randomized, double-blind, placebo-controlled multi-center ...

Phase 2, randomized, double-blind, placebo-controlled multi-center trial of the clinical and biological effects of anti-CD14 treatment in hospitalized patients ...

Safety and efficacy of anti-PCSK9 antibodies: a meta-analysis of 25 ...

Anti-PCSK9 monotherapy for hypercholesterolemia: the MENDEL-2 randomized, controlled phase III clinical trial of evolocumab. J Am Coll ...

Anti-PCSK9 Monotherapy for Hypercholesterolemia

Page 2. M. ANUSCRIPT. ACCEPTED. ACCEPTED MANUSCRIPT. 1. Anti-PCSK9 Monotherapy for Hypercholesterolemia – The MENDEL-2 Randomized,. Controlled ...

A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight ...

We conducted a 56-week, double-blind trial involving 3731 patients who did not have type 2 diabetes and who had a body-mass index (BMI; the ...

The 2 × 2 factorial design: Its application to a randomized trial of ...

The 2 × 2 factorial design calls for randomizing each participant to treatment A or B to address one question and further assignment at random within each ...

CD40 ligand antagonist dazodalibep in Sjögren's disease - Nature

... 2, randomized, double-blinded, placebo (PBO)-controlled trial of DAZ with a crossover stage in two distinct populations of participants with ...

A Phase 2 Randomized Controlled Study of Tralokinumab in ...

Tralokinumab demonstrated an acceptable safety and tolerability profile but did not achieve key efficacy endpoints.

RoB 2: A revised Cochrane risk-of-bias tool for randomized trials

RoB 2 is the recommended tool to assess the risk of bias in randomized trials included in Cochrane Reviews.

Efficacy and Safety of Etrasimod in a Phase 2 Randomized Trial of ...

Absorption, metabolism, and excretion, in vitro pharmacology, and clinical pharmacokinetics of ozanimod, a novel sphingosine 1-phosphate receptor agonist.

Once-Daily Oral Berotralstat for Long-Term Prophylaxis of ...

APeX-2 was a phase 3, parallel-group, multicenter trial in patients with HAE caused by C1-inhibitor deficiency (NCT03485911). Part 1 was a randomized, ...

PEERLESS II: A Randomized Controlled Trial of Large-Bore ... - JSCAI

PEERLESS II is the first randomized clinical trial comparing large-bore MT with standard AC against AC alone for the management of acute ...

A Phase 2, Randomized, Dose-Finding Study of the Novel Once ...

After 12 weeks, semaglutide dose-dependently reduced HbA 1c level and weight in patients with type 2 diabetes. No unexpected safety or tolerability concerns ...

Randomized Controlled Trials (Experimental Studies)

Researchers randomly allocated study participants into 2 groups. The first patient group received weekly classes on meditation practices as well as a self-.

Phase 2, randomized, placebo-controlled trial of dapirolizumab ...

DZP appeared to be well tolerated, and patients exhibited improvements across multiple clinical and immunological measures of disease activity after 24 weeks ...

Efficacy and safety of omalizumab in nasal polyposis: 2 randomized ...

Efficacy and safety of omalizumab in nasal polyposis: 2 randomized phase 3 trials. Philippe Gevaert, MD, PhD.

Phase II Randomized Study of Ramucirumab and Pembrolizumab ...

The July 20, 2022, article by Reckamp et al entitled “Phase II Randomized Study of Ramucirumab and Pembrolizumab Versus Standard of Care in Advanced Non–Small- ...

A phase 2 randomized, double-blinded, placebo-controlled ...

A phase 2 randomized, double-blinded, placebo-controlled, multicenter trial evaluating the efficacy and safety of raloxifene for patients with mild to moderate ...

Randomized Phase II Study of the Safety and Efficacy of ...

This study provides Class I evidence that semorinemab does not slow functional decline in patients with mild-to-moderate AD.

A randomized phase 2 trial of FLEXible and extended dosing of ...

The randomized FLEX-MRT trial aims to generate evidence for an individualized treatment strategy using a flexible and extended dosing schedule of 177 Lu-PSMA ...