The Role of Fatty Acids in Ceramide Pathways and Their Influence ...

Ceramide microdomains: the major influencers of the sphingolipid ...

Like TikTok stars, sphingolipids such as ceramides — though few in number — have a powerful influence on their surroundings. Indeed, ...

Diet-derived and diet-related endogenously produced palmitic acid

Ceramides and branched fatty acid esters of hydroxy fatty acids (FAHFAs), synthesized from palmitic acid, have garnered interest because of ...

Ceramides, sphingolipids, skin, structure, occurrence ... - LIPID MAPS

Ceramides consist of a long-chain or sphingoid base linked to a fatty acid via an amide bond. They are intermediates in the biosynthesis and metabolism of all ...

Very-long-chain fatty acids induce glial-derived sphingosine-1 ...

We report that glia convert these VLCFA into sphingosine-1-phosphate (S1P) via a glial-specific S1P pathway. Excess S1P causes neuroinflammation ...

Fat-Secreted Ceramides Regulate Vascular Redox State and ...

Ceramides and their derivatives have been linked with cardiovascular disease (11,12). In particular, plasma Cer16:0 has been associated with ...

Ceramides in Nutrition-Linked Chronic Disease - Annual Reviews

This review discusses our current understanding of biochemical pathways controlling ceramide synthesis, production and action; influences of ...

The diversity and breadth of cancer cell fatty acid metabolism

Tumor fatty acid metabolism pathways and their role in cancer progression ... acids can impact cancer cell biology beyond their effects on ...

The Role of Lipids in Inducing Insulin Resistance in Humans and ...

Research shows that liver-specific deletion of Cers6 can reduce ceramide levels in the liver, protect against high-fat diet-induced obesity, and ...

Ceramide Lipids Analysis - Lipotype

Aside their biosynthetic role, ceramides function as second messengers in signal transduction and regulate cellular processes by impacting lipid raft properties ...

Ceramide dependent lipotoxicity in metabolic diseases - IOS Press

Studies using lipid infusion or isolated muscles reveal that ceramides are obligate intermediates linking saturated fatty acids, but not ...

Ying and Yang of Ceramide in the Vascular Endothelium

Known activators of the de novo pathway include high cellular palmitate or fatty acids ... pathways can influence vascular function. ROLE OF ...

Advances in determining signaling mechanisms of ceramide and ...

synthase; CRP, ceramide-rich platform; FAO, fatty acid oxidation; Lag1, ... A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism.

Ceramides as the molecular link between impaired lipid metabolism ...

Additionally, the role of specific ceramide subspecies as potential biomarkers for T2DM and the role of both long- and medium-chain saturated fatty acids as a ...

Functional roles of sphingolipids in immunity and their implication in ...

While ceramide blocks the PI3K-Akt-mTOR pathway with PP2A activation to modulate cellular functions such as proliferation and survival, C1P ...

Ceramide analog C2-cer induces a loss in insulin sensitivity in ...

Interestingly, we also show that the exogenous and endogenous monounsaturated fatty acid oleate prevents C2-cer to be recycled into endogenous ...

Ceramide and sphingosine-1-phosphate in cancer, two faces of the ...

Currently, sphingolipids are being studied as potential targets in cancer research due to their role in regulating cellular and pathological processes such as ...

New Evidence for the Role of Ceramide in the Development ... - PLOS

We observed a significant increase in the expression of fatty-acid transport protein (FATP2) and ceramide transfer protein (CERT) what is consistent with ...

Essential Fatty Acids and Skin Health | Linus Pauling Institute

The role of EFAs in the dermis appears to be related to their production of signaling molecules that mediate the inflammatory response. Damage to dermal ...

The Complex Tail of Circulating Sphingolipids in Atherosclerosis ...

Recently, alterations in plasma ceramides with specific N-acyl chain lengths and degrees of saturation have emerged as novel biomarkers for the ...

new targets for novel therapies for fatty liver disease and insulin ...

Compounds of the sphingomyelin (SM)-ceramide (Cer)-glycosphingolipid (GSL) pathways are studied as a potential secondary messenger molecules in various systems, ...