The UPRosome – decoding novel biological outputs of IRE1α function

Claudio Hetz (0000-0003-1120-7966) - ORCID

The UPRosome – decoding novel biological outputs of IRE1α function. Journal of Cell Science. 2020-08-01 | Journal article. DOI: 10.1242/jcs.218107. Part of ISSN ...

CD248 induces a maladaptive unfolded protein response in diabetic ...

∙ Pihán, P. ∙ Hetz, C. The UPRosome—decoding novel biological outputs of IRE1α function. J Cell Sci. 2020; 133:jcs218107.

Chaperon Protein GRP78 Released from MPN Cells Increase ...

Impaired function of the endoplasmic stress (ER) response causes ... The UPRosome – decoding novel biological outputs of IRE1α function.

The role of endoplasmic reticulum stress in the MHC class I antigen ...

The UPRosome - decoding novel biological outputs of IRE1α function. J. Cell. Sci. Aug 11;133(15):jcs218107. doi: 10.1242/jcs.218107. van ...

Restoring TRAILR2/DR5-Mediated Activation of Apoptosis upon ...

The UPRosome—Decoding Novel Biological Outputs of IRE1α Function. J. Cell Sci. 2020,. 133, jcs218107. [CrossRef] [PubMed]. 47. Urano, F.; Wang ...

Assays to Study IRE1 Activation and Signaling

... IRE1α modulate IRE1α activity and protect cells from endoplasmic reticulum stress. ... The UPRosome - decoding novel biological outputs of IRE1alpha function. J ...

Hery Urra (0000-0002-6846-558X) - ORCID

The UPRosome - decoding novel biological outputs of IRE1α function. Journal of cell science. 2020-08 | Journal article. DOI: 10.1242/jcs.218107. PMID: 32788208.

A Non-Canonical Role for IRE1α Links ER and Mitochondria as Key ...

Moreover, some studies have also highlighted a novel role of IRE1α in the ... The UPRosome - decoding novel biological outputs of IRE1alpha function. J ...

F-actin and a Type-II Myosin Are Required for Efficient Clustering of ...

Hery Urra, Philippe Pihán, Claudio Hetz. The UPRosome – decoding novel biological outputs of IRE1α function. Journal of Cell Science. 2020, Vol.133, No.15,.

Life Sciences - UNBC

biological function is yet to be elucidated. As deduced by the ... Hetz, The UPRosome–decoding novel biological outputs of. IRE1α ...

The IRE1α pathway in glomerular diseases: The unfolded protein ...

Endoplasmic reticulum (ER) function is vital for protein homeostasis (“proteostasis”). Protein misfolding in the ER of podocytes (glomerular visceral ...

The Bcl‐2 family protein bid interacts with the ER stress sensor IRE1 ...

The UPRosome - decoding novel biological outputs of IRE1α function. J Cell Sci 133(15):jcs218107. ... 14Zhang P, Su C, Jiang Z and Zheng C (2017) ...

Generic membrane-spanning features endow IRE1α with ...

Secondary effects on protein folding homeostasis likely contribute to UPR activation, but deletion of the unfolded protein stress-sensing ...

The Unfolded Protein Response: Integrating Stress Signals Through ...

IRE1α signaling is a highly regulated process, controlled by the formation of a dynamic scaffold onto which many regulatory components assemble.

Generic membrane-spanning features endow IRE1α with ...

26 May 2020 | Nature Reviews Molecular Cell Biology, Vol. 21, No. 8. The UPRosome – decoding novel biological outputs of IRE1α function. 11 ...

Mechanisms, regulation and functions of the unfolded protein ...

(2) IRE1α. RNase splices XBP1mRNA, which encodes a potent transcription factor that activates expression of UPR target genes involved in ER proteostasis and ...

controlling cell fate decisions under ER stress and beyond - UFRGS

physiological role for this selective output of IRE1α acti- vation. ... suggesting that the IRE1α UPRosome is tuned by the intensity and ...

Endoplasmic reticulum stress activates human IRE1α through ... - eLife

While IRE1's activation is generally thought to involve the formation of dimers and/or larger oligomers, the extent and functional importance of ...

Role of Endoplasmic Reticulum Stress Sensor IRE1α in Cellular ...

... function. Addressing different binding partners that can modulate IRE1α function, UPRosome triggers different downstream pathways depending on the cellular ...