Towards Incorporating Genetics in the ECHO|wide Cohort

Comprehensive Genome-Wide and Phenome-Wide Examination of ...

This study presents first a GWAS of BMI in a cohort without DM2, followed by a GWAS of a cohort with DM2, to identify the differences in the genetic mechanisms ...

Education, Smoking, and Cohort Change - Sage Journals

Taking the relationship between educational attainment and smoking as an exemplary case, we use genome-wide methods to examine whether genetic variants linked ...

Gene-environment interactions within a precision environmental ...

to genome-wide ... scGWAS: landscape of trait-cell type associations by integrating single-cell transcriptomics-wide and genome-wide association ...

An ASD Enriched Risk (ASD-ER) ECHO Cohort - Penn State

While genetic factors are known to influence ASD risk, the underlying ... Child genetic susceptibility will be incorporated into our analyses through ...

ECHO-wide Cohort Data Collection Protocol Version 2.1

Genetics (genotyping to be provided by the. ECHO Genetics Core and optional sub element-epigenetics) e. Person-reported outcomes. Coordinating Center (CC). The ...

Integrating genome-wide polygenic risk scores and non-genetic risk ...

... to predict colorectal cancer diagnosis using UK Biobank data: population based cohort study. Abstract: Objective: To evaluate the benefit of ...

Publications - eMERGE Network

Systems biology approach to late-onset Alzheimer's disease genome-wide ... cohorts to characterize clinical and genetic predictors of treatment outcome.

Cohort-specific imputation of gene expression improves prediction ...

Using eQTL weights to improve power for genome-wide association studies: a genetic study of childhood asthma. Front Genet. 2013;4:103 ...

Genetic Epidemiology | Human Genetics Journal | Wiley Online Library

Incorporating variant annotations in the association tests yielded more genome-wide significant loci compared to the standard kernel-based ...

2 Maximizing Discovery Capabilities Through Cohort Design

Large-scale genetic cohort studies point to the value of widespread national ... “You cannot pursue modern drug discovery and development without incorporating ...

Genome UK: 2022 to 2025 implementation plan for England - GOV.UK

Our Future Health plans to genotype the world's largest population cohort to ... genome-wide imputation data on up to 5 million participants. This ...

Toward the Last Cohort | American Association for Cancer Research

Thus, there is a wide variety of genetic susceptibilities to, and protection against, these exposures. ... incorporating family and genetic ...

"A Genome-Wide Association Study of Red-Blood Cell Fatty Acids ...

... Incorporating Dietary Covariates: Framingham Heart Study Offspring Cohort ... wide association studies continue to uncover additional genes ...

The complex genetic architecture of Alzheimer's disease: novel ...

Progressively larger genome-wide association studies (GWAS) have continued to expand our knowledge of AD/dementia genetic architecture.

Multiancestry Genome-Wide Association Study of Lipid Levels ...

Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. InterAct Consortium, LifeLines Cohort Study Grp. Life ...

A multi-ancestry genome-wide study incorporating gene-smoking ...

A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure · Abstract ...

Interplay between genome-wide implicated genetic variants and ...

... genetic variants and environmental factors related to childhood antisocial behavior in the UK ALSPAC cohort ... to GWAS top hits, incorporate ...

Toward Capturing Genetic Epistasis From Multivariate Genome ...

Refer to caption Figure 1: Genome-wide association study [5] . ... cohorts, they can be incorporated to further assist with matrix ordering.

Genetic Risk Factors Associated With Preeclampsia and ...

For the fetal and paternal genome-wide association analysis, samples from the FINNPEC cohort were available. ... cohort to examine overall genetic ...

Returning integrated genomic risk and clinical recommendations

Basford, et al. PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations. Bioinformatics, 26 (9) (2010), pp. 1205 ...