Transcription Factors in Lymphocyte Development

Transcription Factors in Lymphocyte Development— T and B Cells ...

Transcription Factor Expression in Lymphocyte Development: Clues ...

... B cells and T cells in the cartilaginous fish (Litman et al. 1999) indicates the occurrence of at least one major event pivotal for the development of ...

Transcription factor PU.1 and immune cell differentiation (Review)

During T lymphocytes, cells undergo at least three major transcription factor action stages before they are fully programmed, including the ...

Clues to the Evolutionary Origins of Lymphoid Cell Lineages?

1998) may have provided another powerful mechanism for rapid evolutionary change. Lymphoid development is dependent upon networks of transcription factors, ...

Transcription Factors - BioLegend

... transcription factors expressed by various cell types, including T cells ... B cell development in mammals was mainly found to occur in the bone marrow ...

Systems-level identification of key transcription factors in immune ...

Transcription factors (TFs) are crucial for regulating cell differentiation during the development of the immune system. However, the key TFs ...

B cell development is critically dependent on NFATc1 activity - Nature

Apart from IL-7 signaling, a host of lineage-specific transcription factors (TF) have been implicated in the regulation of early B cell ...

TRANSCRIPTIONAL REGULATION OF T LYMPHOCYTE ...

The development and function of T lymphocytes are regulated tightly by signal transduction pathways that include specific cell-surface receptors, intracellular ...

Evolutionary Origins of Lymphocytes: Ensembles of T Cell and B ...

In contrast, most of the transcription factors that are essential for the development of mammalian T and B lymphocytes belong to multigene families that are ...

Understanding B Lymphocyte Development: A Long Way to Go

Transcription factors (TFs) play vital role during the entire process of B cell development and maturation from HSCs [84, 85, 86]. The entire process involves ...

Gene enrichment profiles reveal T-cell development, differentiation ...

This development depends upon Notch and Wnt signaling pathways and transcription factors including GATA3, MYB, RUNX1, IKZF1, and TCF7 (for ...

Identification of E2A target genes in B lymphocyte development by ...

The transcription factors encoded by the E2A gene are known to be essential for B lymphocyte development, and ectopic expression or gene inactivation ...

Characterization of Early Stages of Human B Cell Development by ...

Several transcription factors with unknown roles in B lymphoid cells demonstrated interesting expression patterns, including ZCCHC7 and ZHX2.

Lymphocyte development and disease

Proper transcriptional control at each cellular transition is essential for the correct development of B lymphocytes. How specific gene expression programmes ...

Functional definition of a transcription factor hierarchy regulating T ...

The core set of transcription factors in the early phases of T cell development is T cell factor 1 (Tcf1) (encoded by the gene confusingly ...

The Route of Early T Cell Development: Crosstalk between ... - MDPI

The functional relationship between these major first transcription factors (Tcf1, Bcl11b and Gata3) that shape the T cell gene program has long been unclear.

Tcf-1 Enforces Epigenetic Identity In Developing T Cells And T-Bet ...

During immune responses, some activated B lymphocytes express the transcription factor T-bet, but the clonal relationship to their T-bet- ...

Gene Expression during the Activation of Human B Cells - IntechOpen

BACH1 and BACH2 promote B cell development by repressing the myeloid program [32]. They belong to the basic region–leucine zipper family and are transcription ...

Serum Response Factor Contributes Selectively to Lymphocyte ...

To determine the in vivo role of SRF in developing lymphocytes, we specifically inactivated the murine Srf gene during T or B cell development using lymphocyte- ...

Transcriptional Control of Early T and B Cell Developmental Choices

T and B cells share a common somatic gene rearrangement mechanism for assembling the genes that code for their antigen receptors; ...

Transcription Factor Expression in Lymphocyte Development: Clues ...

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