the balancing act of BCL|2 family proteins

Bcl-2 - an overview | ScienceDirect Topics

Bcl-2 is a 26-kDa protein that is part of a family of proteins involved in regulating cell death. It is located at contact sites between the inner and outer ...

Ancient and conserved functional interplay between Bcl-2 family ...

Proapoptotic BH3-only proteins tip the balance toward cell death. At the functional level, BH3-only proteins can be divided into activators and ...

Mechanisms of BCL-2 family proteins in mitochondrial apoptosis.

The functional interplay and balance between the opposing BCL-2 family ... Regulation of apoptosis in health and disease: the balancing act of BCL ...

Apoptosis Regulators Bcl-2 and Caspase-3 - MDPI

Regulation of apoptosis in health and disease: The balancing act of BCL-2 family proteins. Nat. Rev. Mol. Cell Biol. 2019, 20, 175–193. [Google Scholar] ...

Bcl-2 Family - Creative Biolabs

... proteins, thus shifting the balance towards cell death. The regulation ... The proteins of this family form hetero- or homodimers and act as anti- and ...

BCL-2 Family Proteins: Critical Checkpoints of Apoptotic Cell Death

The unique localizations, protein associations, and mechanisms of activation for these individual BH3-only proteins suggest that each acts as a ...

B-cell lymphoma 2 (Bcl-2) protein family

The Bcl-2 proteins form a family of evolutionarily related proteins which are essential for maintaining the balance between cell death and cell proliferation.

Multiple Functions of BCL-2 Family Proteins

In this sce- nario, BAX is thought to act downstream of. NGF withdrawal by classical apoptosis mecha- nisms (see below). As expected, BAX promotes cell death in ...

Emerging Role for Members of the Bcl-2 Family in Mitochondrial ...

BH3- only proteins act as sensors for cell stress, damage, infection, growth factor deprivation, and other signals that provoke apoptosis (Puthalakath and ...

The C-terminal sequences of Bcl-2 family proteins mediate ...

K. (. 2019. ) Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins . Nat. Rev. Mol. Cell Biol. 20. ,. 175.

Bcl-B: an “unknown” protein of the Bcl-2 family | Biology Direct

This process might also act as an essential adaptive mechanism for the maintenance of cell survival by preventing apoptosis [33, 34]. Bcl-B ...

The role of BCL-2 family proteins in regulating apoptosis and cancer ...

... BCL-2 family proteins in the therapy of cancer. List of references. Singh, Regulation of apoptosis in health and disease: the balancing act of BCL-2 family ...

(PDF) Control of apoptosis by the BCL-2 protein family - ResearchGate

BAX and cause its activation (Gavathiotis et al., 2008; 2010). This interaction may act to displace the BAX α9 helix from. the canonical groove ...

Emerging biomarkers and potential therapeutics of the BCL-2 ...

Singh R, Letai A, Sarosiek K (2019) Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins. Nat Rev Mol ...

Mechanisms of Action of Bcl-2 Family Proteins

It also explains how other membrane sites such as the Golgi can act as a reservoir for potentially activated Bax (Dumitru et al. 2012). Therefore, the roles of ...

Bcl-2–family proteins and hematologic malignancies

... a balance under normal circumstances. This ability to control cell ... Bcl-2 and causing it to function as a proapoptotic protein. A ...

Targeting Anti-Apoptotic BCL-2 Family Proteins for Cancer Treatment

Singh R , LetaiA , SarosiekK. Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins. Nat. Rev. Mol. Cell Biol.20 ...

Bok is a pro-apoptotic Bcl-2 protein with restricted expression in ...

Bcl-2-related proteins act upstream from caspases in the cell death pathway (6). Recent studies demonstrated that another C. elegans gene, ced-4, or its ...

The Role of BCL2 Family of Apoptosis Regulator Proteins in Acute ...

BCL2 might also regulate the activation of several initiator caspases like caspase-2 that act upstream or independently of cytochrome c release ...

Toward Targeting Antiapoptotic MCL-1 for Cancer Therapy

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins. Nat. Rev. Mol. Cell Biol. 20:175–93. [Google ...