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A transcriptome|wide association study based on 27 tissues ...


Transcriptome-Wide Association Study Identifies New Candidate ...

8), which is based on GTEx version 7 eQTL data (Supplementary Table S2). To combine S-PrediXcan data across the different brain tissues taking into account ...

On the interpretation of transcriptome-wide association studies

association study based on 27 tissues identifies 106 genes potentially relevant for disease ... A statistical framework for cross-tissue ...

Transcriptome-wide association study-derived genes as potential ...

It is well known that visceral adipose tissue (VAT) is more harmful than adipose tissue from other locations [3], such as subcutaneous adipose ...

Enhancer RNA transcriptome-wide association study ... - medRxiv

to arrange the tissues based on their similarity in eRNA-QTL sharing patterns. (E) Proportion of tissues sharing lead eRNA-QTLs/eQTLs across ...

The impact of sex on gene expression across human tissues - Science

By integrating sex-biased eQTLs with genome-wide association study data, we ... Lander, J. P. Mesirov, Gene set enrichment analysis: A knowledge-based approach ...

Transcriptome-wide association study and Mendelian randomization ...

PDAC, pancreatic adenocarcinoma; T2D, type 2 diabetes; VTE, venous thromboembolism; JTI, Joint-Tissue Imputation; UTMOST, unified test for molecular signatures.

Integrating predicted transcriptome from multiple tissues improves ...

Integration of genome-wide association studies (GWAS) and expression quantitative trait loci (eQTL) studies is needed to improve our ...

The Transcriptome-Wide Association Study (TWAS) in Alzheimer's ...

Following within-tissue normalization and covariate adjustment, predictive weights to impute expression components based on a gene's surrounding cis-variants ...

TWAS: Transcriptome-wide association study - Front Line Genomics

Opportunities. Gene expression is a heritable, complex trait which varies across different tissues. TWAS is able to predict gene expression for ...

Oral health - World Health Organization (WHO)

... tissues and further progressing to involve the hard tissues and skin of the face. ... wide variation in different studies and populations (1).

Hepatic and adipose tissue transcriptome analysis highlights a ...

... 27 with severe MASLD (S) (Figure S1A). Study design and clinical ... The association between circulating CTSD and liver damage was ...

DECIPHER v11.28: Mapping the clinical genome

... based on gnomAD v4.1, are now available on gene pages. These scores measure the amount that a gene is constrained for missense variants. DECIPHER v11.27 ...

Breast cancer - World Health Organization (WHO)

In contrast, in countries with a low HDI; while only 1 in 27 women is diagnosed with breast cancer in their lifetime, 1 in 48 women will die ...

Anatomy - Wikipedia

Anatomy is the branch of morphology concerned with the study of the internal structure of organisms and their parts. Anatomy is a branch of natural science ...

Problem Drinking Contributors Unearthed Using Mendelian ...

NEW YORK – A National Institutes of Health-led team has identified brain proteins and cell type-related genes with ties to alcohol use ...

Systemic Lupus Erythematosus (SLE) - Medscape Reference

A population-based study from Denmark found that the hazard ratio ... Genome-wide association studies have identified more than 60 risk ...

Molecular Mechanisms of Heterosis and Its Applications in Tree ...

Building on this, CRISPR-based gene-editing technologies can be employed ... Genome-wide association studies (GWAS) have identified numerous key genes ...

DNA - Wikipedia

A chromosome and its packaged long strand of DNA unraveled. The DNA's base pairs encode genes, which provide functions. A human DNA can have up to 500 million ...

Chronic stress puts your health at risk - Mayo Clinic

... tissues. Cortisol also slows functions that would be nonessential or harmful in a fight-or-flight situation. It changes immune system responses and ...

What is HSD? - The Ehlers Danlos Society

Hypermobility spectrum disorders (HSD) are connective tissue disorders that cause joint hypermobility, instability, injury, and pain.