- Gene Therapy With the N|Terminus of Junctophilin|2 Improves Heart ...🔍
- Reversal of contractile defects by mediating calcium homeostasis in ...🔍
- State of Gene Therapy for Monogenic Cardiovascular Diseases🔍
- Gene Therapy🔍
- Cardiac AAV:PKP2 Gene Therapy Reduces Ventricular Arrhythmias ...🔍
- AAV|mediated gene therapy🔍
- Gene therapy to reverse heart failure ready for clinical trials🔍
- Gene and cytokine therapy for heart failure🔍
AAV Gene Therapy Prevents and Reverses Heart Failure in A ...
Gene Therapy With the N-Terminus of Junctophilin-2 Improves Heart ...
AAV Gene Therapy Prevents and Reverses Heart Failure in a Murine Knockout Model of Barth Syndrome · Medicine. Circulation research · 2020.
Reversal of contractile defects by mediating calcium homeostasis in ...
After dosage optimization, AAV-mediated expression of SERCA2a abrogated the disease phenotype and improved the cardiac kinetics in HFpEF mini- ...
State of Gene Therapy for Monogenic Cardiovascular Diseases
Of note, several AAV-based clinical trials have been conducted for cardiac regeneration, ischemic heart disease, and heart failure.
Gene Therapy: The Age of AAV - Wyss Institute
AAV has moved into the focus of several companies that are developing treatments of different diseases, including blindness in the form of the ...
• In a mode of disease progression, cardiac AAV:PKP2 gene therapy 1) Reverses RV enlargement and prevents decline of LV function; 2) Demonstrates increased ...
AAV-mediated gene therapy: Advancing cardiovascular disease ...
For nearly three decades, adeno-associated virus (AAV) has shown significant therapeutic benefits in multiple clinical trials, mainly due to its ...
Gene therapy to reverse heart failure ready for clinical trials
PHILADELPHIA—A promising gene therapy developed, in part, at Thomas Jefferson University's Center for Translational Medicine to prevent and ...
Gene and cytokine therapy for heart failure: molecular mechanisms ...
The therapeutic potential of SERCA2a gene transfer to failing heart has been evaluated in small animal model of HF. Intracoronary adenovirus-encoding SERCA2a ...
Recent findings into the potential of gene therapy to reverse heart ...
AAV vectors have been recently used to address long-term therapeutic effectiveness of both S100A1 and S16PLN transgenes in chronic animal post- ...
Designing a PKP2 Gene Therapy to Target Cardiomyocytes for ...
Kyriakopoulou et al. showed that treatment with AAV9-based PKP2 gene therapy prevented cardiac dysfunction in an alternate ARVC mouse model, ...
Intrastromal Gene Therapy Prevents and Reverses Advanced ...
To investigate the therapeutic efficacy and tolerability of AAV-IDUA gene therapy for MPS I corneal disease, we employed a naturally occurring canine model ( ...
The Use of Gene Therapy for Ablation of Atrial Fibrillation
The principal disadvantage of AAV vectors is the limited insert size, preventing use with some ion channels or other large genes. Recent cardiac ...
... her recent publication: "AAV gene therapy prevents and reverses heart failure in a...
Non-cell-Autonomous Cardiomyocyte Regulation Complicates Gene ...
... gene therapy for Lmna-associated cardiac defects. ... "AAV gene therapy prevents and reverses heart failure in a murine knockout model of Barth syndrome".
Gene therapy vector-related myocarditis
neurohormonal response to cardiac failure as opposed to treatment ... Immunosuppression protocols used in human AAV-delivered gene therapy trials ...
Micro-dystrophin gene therapy prevents heart failure in an improved ...
We used this model to demonstrate for the first time to our knowledge that AAV-μDys postnatal delivery is efficacious at preventing heart ...
Nerve Growth Factor Gene Therapy Using Adeno-Associated Viral ...
To the best of our knowledge, the possibility that cardiac NGF gene transfer could prevent diabetes-induced cardiomyopathy has not previously ...
heart failure are making progress in the clinic. Rocket Pharmaceuti- cals aims shortly to start a pivotal phase 2 study of a gene therapy.
CRISPR gene editing may help treat heart disease after a heart attack
Researchers say a new CRISPR gene editing therapy may help treat heart disease. The scientists also found evidence the therapy can help ...
Gene Therapy for the Heart - ArTS
cially in DCM, the cDNAs of several of the genes that cause the disease are too large to fit into conventional. AAV vectors. ... heart failure patients: the STOP- ...