Chemical genetic approaches to dissect microbiota mechanisms in ...

Faculty Mentors | Genetics and Developmental Biology Training ...

... dissect molecular and cellular mechanisms of hematopoiesis. As a ... Their approaches include molecular genetics, genomics, computational biology ...

Plant chemical genetics reveals colistin sulphate as a SA and NPR1 ...

Zheng, W. et al. Bestatin, an inhibitor of aminopeptidases, provides a chemical genetics approach to dissect jasmonate signaling in Arabidopsis.

Towards a mechanistic understanding of reciprocal drug ...

Microbiome–drug interactions are bidirectional, as microbes can also modulate drugs. Chemical modifications of antibiotics mostly function as ...

Systematic mapping of antibiotic cross-resistance and collateral ...

Among correlation methods, six chemical genetics derived ... Chemical genetics can infer mechanisms and monochromaticity. 734 of ...

Chemical Genetics Reveals Bacterial and Host Cell Functions ...

Chemical genetic screening provides a novel approach to probe the host cell functions and factors involved in host–pathogen interactions.

Kevan Shokat, PhD | UCSF Macromolecular Structure Group

Chemistry & biology. Crews C, Shokat K, Suga H, Kostic M. A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development.

Expanding the genetic toolkit helps dissect a global stress response ...

Our findings in an early-branching bacterium reveal surprising parallels to and differences from the σE response in well-characterized model bacteria, and ...

Chemical Biology Applied to the Study of Bacterial Pathogens

In recent years, chemical biology and chemical genomics have been increasingly applied to the field of microbiology to uncover new potential ...

Mechanisms of Genome Control - German Cancer Research Center

We combine state-of-the-art genomic, proteomic and computational biology approaches with high-throughput genetic engineering to dissect gene regulatory ...

Molecular Mechanisms of Dietary β-Glucan Utilization

Firmicutes. A phylum of Gram-positive bacteria, members of which predominate in the HGM. The term “Gram-positive PUL (gpPUL)” has been coined to ...

Key features of the genetic architecture and evolution of host ... - eLife

To gain deeper understanding of the role of host genetics in shaping gut microbial traits, we employed a powerful genetic mapping approach using ...

ﬁmicrobiome interactions - EMBO Press

Microbiome–drug interactions are bidirectional, as microbes can also modulate drugs. Chemical modifications of antibiotics mostly function as.

Organoid-based chemical approach to dissect the mechanism ...

They can be cultured long-term and are easily amenable to genetic, molecular, and cellular analyses. Organoids can be derived from embryonic stem cells, induced ...

Mechanistic Dissection of Host-Microbiome Relationships. - Abstract

A complex network of interactions between host genetic factors, microbes, and microbial metabolites governs intestinal homeostasis, making classification and ...

A genomic toolkit for the mechanistic dissection of intractable human ...

Here, we demonstrate the utility of conducting an in-depth analysis of a single class of neglected, but clinically relevant human gut bacteria for which genetic ...

Multi-omics approaches to disease | Genome Biology | Full Text

Genomics is the most mature of the omics fields. In the realm of medical research, genomics focuses on identifying genetic variants associated ...

Dissecting cause and effect in host- microbiome interactions using ...

... molecular mechanisms underlying the effects of microbial genes on general health and ageing3. Available models to study the effect of the gut microbiota on ...

Introducing THOR, a Model Microbiome for Genetic Dissection of ...

The quest to manipulate microbiomes has intensified, but many microbial communities have proven to be recalcitrant to sustained change.

Dissect worm | Sigma-Aldrich

Genetic approaches in flies and worms continue to dissect the intricate molecular machinery of chemical synapses. Investigations carried ...

Research - UTHealth School of Dentistry

Using molecular genetics approach, we are deciphering the mechanisms of interferences of Streptococcus mutans quorum sensing by other oral bacteria. We are ...