Cofilin Loss in Drosophila Muscles Contributes to ...

Dominant Negative Mutant Actins Identified in Flightless Drosophila ...

More- over, the myosin-induced conformational changes appear to be cooperative (7–9), e.g. Ca2⫹-triggered conformational changes in the skeletal muscle actin ...

Roles of cofilin in development and its mechanisms of regulation

Loss of sickie, a. Drosophila ortholog of the mammalian microtubule- associated protein neuron navigator 2 (NAV2 MAP), sup- presses axon ...

Mayday sustains trans-synaptic BMP signaling required for ... - eLife

Finally, we examined knockdown of myd in muscle tissue (MHC-Gal4) and found a progressive loss of flight (Figure 4E), similar to the phenotype ...

Regulation of Growth Cone Actin Dynamics by ADF/Cofilin

Several lines of evidence point towards AC as a crucial protein in growth cone motility. This section focuses on how the unique activities of AC may serve to ...

Cofilin-1 and Other ADF/Cofilin Superfamily Members in Human ...

Overexpression of cofilins leads to the formation of stress fibers, contractile actin bundles that have been found in non-muscle cells and shown ...

Actin Filaments A Target for Redox Regulation

cofilin) [Minamide et al., 2010]. ... tion of mechanosensory organs, as depicted here where a loss of Mical (KO, Drosophila Mical2/2 mutants) generates ...

Actin Dynamics, Regulated by RhoA-LIMK-Cofilin Signaling ... - IOVS

LIMK is an upstream regulator of cofilin that contributes to actin filament turnover. To understand the impact of retinal detachment on actin dynamics, we first ...

Drosophila Model to Study Muscle Atrophy

Using a collection of 'readout proteins' with different sensitivity to actin loss, we conducted a small-scale genetic screen, aiming to identify genes that ...

rabbit muscle actin: Topics by Science.gov

Taken together, we demonstrate that CryAB ensures myofibrillar integrity in Drosophila muscles ... Loss of Fascin results in decreased nuclear Cofilin. In ...

2 - OUCI

Various heterozygous cytoskeletal γ-actin mutations have been shown to cause Baraitser–Winter cerebrofrontofacial syndrome, non-syndromic hearing loss, or ...

Loss of Modifier of Cell Adhesion Reveals a Pathway Leading to ...

The loss of MOCA in mice leads to axonal degeneration and causes sensorimotor impairments by decreasing cofilin phosphoryla- tion and altering its upstream ...

Functions of the cardiomyocyte's non-sarcomeric cytoskeleton

Due to the intricacies of these networks, the dysregulation and dysfunction of cytoskeletal proteins can have dire consequences for heart function and culminate ...

Twinfilin is required for actin-dependent developmental processes in ...

Mutations in the Drosophila ADF/cofilin homologue, twinstar, lead to defects in centrosome migration, cytokinesis, and border cell migration (Edwards et al., ...

Tropomyosin isoforms: divining rods for actin cytoskeleton function

activity and loss of Tm1. ... Tm5NM1 promotes inactivation of ADF-cofilin by phosphorylation and leads to displacement of ADF-cofilin from the ...

from actin oxidation to membrane traffic during cytokinesis - HAL

Indeed, a recent study demonstrated that F-actin filaments oxidized by. Drosophila Mical are more sensitive to cofilin-induced severing in vitro ...

Synaptic Properties and Plasticity Mechanisms of Invertebrate Tonic ...

Studies in muscles of the cat limb described a behavioral parallel to some of the crustacean work, with tonic and phasic outputs implicated in ...

Insectes Catalogue en ligne - Myobase

... contributes to oculopharyngeal muscular dystrophy through muscle atrophy ... Loss of Fis1 impairs proteostasis during skeletal muscle aging in Drosophila.

ADF/Cofilin family - Wikipedia

This dynamic instability is central to actin's role in muscle contraction, cell motility and transcription regulation. Cartoon representation of a cofilin ( ...

Tropomyosin isoforms differentially affect muscle contractility in the ...

and body regions of the muscles and contribute differentially to the regulation of muscle ... Troponin C isoforms in Drosophila adult muscles. Mol Biol Cell 28,.

Alpha-Spec Antibody (3A9 (323 or M10-2)) - DSHB

... loss of activity, shelf-life at 4°C is highly variable. ... Hormone receptor 4 is required in muscles and distinct ovarian cell types to regulate specific steps ...