Contribution of Humanized Liver Chimeric Mice to the Study of ...

Assessment of chimeric mice with humanized livers in new drug ...

1. Chimeric mice with humanized livers are expected to be a novel tool for new drug development. This review discusses four applications where these animals ...

Near Completely Humanized Liver in Mice Shows Human-Type ...

These results indicate that human hepatocytes that propagate in mice retain their normal pharmacological responses. We conclude that the chimeric mouse ...

Liver-humanized mice to study hepatis B virus infection

Excitingly, most NSG-PiZ mice tolerated PHH engraftment and the chimeric mouse liver was shown to be functional by detection of secreted serum ...

Humanized mice with ectopic artificial liver tissues - PNAS

Mice transplanted with HEALs exhibit humanized liver functions persistent for weeks, including synthesis of human proteins, human drug metabolism, drug–drug ...

Humanized mice efficiently engrafted with fetal hepatoblasts and ...

Human liver chimeric mice are useful models of human hepatitis virus infection, including hepatitis B and C virus infections. Independently, immunodeficient ...

In vivo drug metabolism model for human cytochrome P450 enzyme ...

Chimeric mice with humanized liver, which were established using urokinase-type plasminogen activator (uPA)+/+/severe combined immunodeficient (SCID) mice by ...

Liver-Humanized NSG-PiZ Mice Support the Study of Chronic ...

To combat HBV species restrictions and enable more in vivo studies, liver-humanized mouse models have been developed that are permissive to HBV ...

Human-animal chimeras for autologous organ transplantation

Excitingly, the latest research showed that xenotransplantation of a pig heart with α-1,3-galactosyltransferase-knockout combined with human CD46 and ...

Publications | Yecuris FRG: Liver-Humanized Mice & Preclinical ...

A Humanized Mouse Model for Plasmodium vivax to Test Interventions that Block Liver Stage to Blood Stage Transition and Blood Stage Infection. Schäfer C, ...

Assessment of amiodarone-induced phospholipidosis in chimeric ...

Chimeric mice with a humanized liver are expected to predict hepatotoxicity in humans. Drug-induced phospholipidosis (DIPL), in which phospholipids accumulate, ...

A mouse model of humanized liver shows a human-like lipid profile ...

We examined the suitability of mice with a humanized liver as a model for lipoprotein studies and studies on plaque formation, given the central ...

Humanization of Excretory Pathway in Chimeric Mice with ...

We previously reported that the chimeric mice with humanized liver could be useful as a human model in studies on drug metabolism and pharmacokinetics. In the ...

Modeling NAFLD in Humanized Mice: Upgrading Preclinical ...

The central role of liver metabolic disturbances in the development of NAFLD makes chimeric mice with humanized liver (Hu-liver) a valuable tool. Published ...

PXB-mouse: Overcoming species-to-species differences to ...

The PXB-mouse® model, with its humanized liver, provides a highly predictive model of human physiology and human-specific hepatotoxicity, ...

Emerging technologies and ethics—exogenic chimeric humanized ...

In these previously reported chimeric mouse studies, human stem cells have formed entire organs (thymus or liver) and have contributed ...

Innovations, challenges, and minimal information for standardization ...

Human liver chimeric mice have also been used to model metabolic disorders. The first xenograft model for metabolic liver disease was ...

Humanized chimeric mouse models of hepatitis B virus infection

To restructure the liver of mice with xenogeneic hepatocytes, the uPA mice were associated with genetically immunodeficient mouse strains, such ...

Comparative Transcriptomics Analyses in Livers of Mice, Humans ...

Mouse is the most widely used animal model in biomedical research, but it remains unknown what causes the large number of differentially regulated genes ...

Human hepatic stem cells transplanted into a fulminant hepatic ...

Chimeric mice with humanized livers were recently established by transplanting human hepatocytes. This mouse model that is repopulated with ...

Human liver chimeric mouse model based on diphtheria toxin ...

Human hepatocytes were successfully repopulated in the livers of ADSB mice. The inducible mouse model of humanized liver in ADSB mice may have ...