Correlation of the treatment sensitivity of patient| derived organoids ...

Patient-Derived Organoids Show Promise for Personalized Therapy ...

Grossman JE, Huang L, Muthuswamy L, et al. Organoid sensitivity in pancreatic cancer correlates with clinical response to treatment and reveals ...

Culture media composition influences patient-derived organoid ...

PDO therapeutic agent sensitivity correlates with patient tumor response. (A) CT scans of donor patient for PDO HO20 before and after treatment ...

Patient-Derived Organoids on a Microarray for Drug Resistance ...

Establishment of the Breast Cancer Patient-Derived Organoids (BCOs). Fresh tissues of breast cancer patients were collected at the First ...

PATIENT-DERIVED INTESTINAL ORGANOIDS PREDICT DRUG ...

Change in total Mayo scores at weeks 0 and 24 were correlated with organoid viability. Results: Tofacitinib at 1 and 10 μM significantly rescued the decreased ...

Establishment of Patient-Derived Organoids Using Ascitic or Pleural ...

Immunohistochemical staining of breast cancer organoids showed molecular features identical to those of tumor tissues. In drug sensitivity ...

1 Patient-derived xenografts and organoids model therapy response ...

In this study, we describe the development of a PDX model derived from a treatment-naïve soft tissue metastasis (PNPCa), with androgen sensitive.

Volumetric growth tracking of patient-derived cancer organoids ...

Single-organoid tracking improved sensitivity to drug treatment compared to a pooled analysis of changes in organoid volume. OCT provided a more accurate ...

Targeting mutant RAS in patient-derived colorectal cancer ... - eLife

Libraries of patient-derived tumor organoids are a reliable and scalable model system that can help identify and optimize targeted therapies ...

Drug Sensitivity Assays of Human Cancer Organoid Cultures

Importantly, the systematic sensitivity testing of organoid cultures to anticancer drugs identified clinical gene–drug interactions, suggestive of their ...

Patient‐derived organoids, creating a new window of opportunities ...

Standard‐of‐care regimens for pancreatic ductal adenocarcinoma (PDAC) include a combination of chemotherapies, which are associated with ...

Organoid Sensitivity Correlates with Therapeutic Response in ...

For most patients, there are no options for targeted therapy, and existing treatments are limited by toxicity. The HOPE trial (Harnessing Organoids for ...

Patient-derived Organoid Model for Predicting the Chemoresponse ...

Their study reported a sensitivity of 63.33%, specificity of 94.12%, and accuracy of 79.69% in the PDTO model for predicting responses to chemotherapy regimens.

Unlocking the potential of patient-derived organoids ... - UCLA Health

Additionally, they found the drug responses observed in the lab matched how the patients themselves responded to treatment for a small number of ...

Patient-Derived Tumor Organoids Can Predict the Progression-Free ...

Recent studies have shown patient-derived tumor organoids can predict the drug response of patients with cancer. However, the prognostic value of patient- ...

Prospective experimental treatment of colorectal cancer patients ...

Organoid technology has recently emerged as a powerful tool to assess drug sensitivity of individual patient tumors in vitro.

Treatment response prediction with circulating tumor cell-derived ...

In this study, we test if drug sensitivity profile of short-term culture of tumor organoids derived from circulating tumor cells (CTCs) correlates to clinical ...

PDX-derived organoids model in vivo drug response ... - JCI Insight

Patient tumor-derived organoid (PDO) models are quickly evolving as a method to model a patient's disease ex vivo. We and others have reported ...

P18.15.B DRUG SENSITIVITY OF RECURRENT GBM PATIENT ...

P18.15.B DRUG SENSITIVITY OF RECURRENT GBM PATIENT-DERIVED ORGANOIDS CORRELATES WITH PATIENTS' RESPONSE TO SECOND LINE CHEMOTHERAPY. M Morelli ,.

Organoids as a biomarker for personalized treatment in metastatic ...

Abstract Background The inability to predict treatment response of colorectal cancer patients results in unnecessary toxicity, decreased efficacy and ...

Patient-derived organoids in human cancer: a platform for ...

The accuracy was determined to be 84.43%, with a sensitivity of 78.01%. The results also indicated a specificity of 91.97%, further highlighting ...