Dual IGF1R/IR inhibitors in combination with GD2|CAR T|cells ...

Focal Adhesion- and IGF1R-Dependent Survival and Migratory ...

However, the combination mTOR and IGFR/IR inhibitors, even at lower con- centrations, dramatically induced melanoma cell death. To inves ...

A dual-specific IGF-I/II human engineered antibody domain inhibits ...

The eAd suppressed the signal transduction of IGF-1R mediated by exogenous IGF-I or IGF-II in breast cancer cell lines through neutralizing both IGF-I and IGF- ...

Development of a 4-aminopyrazolo[3,4-d]pyrimidine-based dual ...

Both the type I insulin-like growth factor receptor (IGF1R) and Src pathways are associated with the development and progression of numerous ...

The Combination of Insulin-Like Growth Factor Receptor 1 (IGF1R ...

A previous phase I trial with an IGF1R inhibitor has demonstrated biological activity against ACC. The objective of this study is to assess the ...

Uso combinato di cellule CAR-T e inibitori bivalenti di IGF1R/IR: una ...

Dual IGF1R/IR inhibitors and CAR-T cells combination: a new strategy to improve Neuroblastoma therapy. Abstract in italiano. Il Neuroblastoma è un tipo di ...

IGF1R- and ROR1-Specific CAR T Cells as a Potential Therapy for ...

The adoptive transfer of IGF1R and ROR1 CAR T cells derived from a sarcoma patient significantly reduced tumor growth in pre-established, systemically ...

Insulin-like Growth Factor-1 Synergizes with IL-2 to Induce ... - bioRxiv

These data support the potential use of IGF1 in combination with common γ-chain cytokines to drive T cell expansions both in vitro and in vivo ...

CAR T-Cell Therapy in Children with Solid Tumors

Dual IGF1R/IR inhibitors in combination with GD2-CAR T-cells display a potent anti-tumor activity in diffuse midline glioma H3K27M-mutant ...

‪Biagio De Angelis‬ - ‪Google Scholar‬

Dual IGF1R/IR inhibitors in combination with GD2-CAR T-cells display a potent anti-tumor activity in diffuse midline glioma H3K27M-mutant. E de Billy, M ...

Insulin-like Growth Factor-1 Synergizes with IL-2 to Induce ...

Despite this propensity for IGF1 to impact Tregs, the mechanisms by which this growth factor engages the IGF1R and induces downstream PI3K/Akt signaling (29) ...