Elucidating the Epigenetic Landscape of Type 2 Diabetes

Exploring the key role of DNA methylation as an epigenetic ...

Type 2 diabetes mellitus (T2DM) is a multifactorial metabolic disorder characterised by impaired insulin secretion and action, often exacerbated ...

Epigenetic regulation in diabetic vascular complications in

This review summarizes aberrant epigenetic regulation under diabetic conditions, including histone modifications, DNA methylation, and non- ...

Impact of Glycemic Variability on Chromatin Remodeling, Oxidative ...

Intensive glycemic control (IGC) targeting HbA1c fails to show an unequivocal reduction of macrovascular complications in type 2 diabetes ...

Metabolic consequences of obesity and type 2 diabetes - Cell Press

). The search for genetic variants that contribute to common forms of obesity and diabetes began slowly with candidate gene and genome-wide ...

Elucidation of Epigenetic Landscape in Coronary Artery Disease

This indicates that we need to work on precision medicine to discover the diagnostic, therapeutic, and prognostic targets to improve the outcome of CAD. In ...

Analysis of global DNA methylation and epigenetic modifiers ...

Both hypermethylation and hypomethylation have been reported in diabetes, suggesting their possible involvement in disease onset and progression by regulation ...

Epigenetics and life-long consequences of an adverse nutritional ...

2004). Pancreatic islet transplantation in pregnant diabetic rats could improve glucose homeostasis in the offspring (Aerts & van Assche 1992). ... 2012). It was ...

Elucidating the Beneficial Role of PPAR Agonists - ProQuest

Elucidating the Beneficial Role of ... type 2 diabetes, dyslipidemia, and cardiovascular diseases. ... Apparently, exercise alters the epigenetic landscape ...

‪Djeane Debora Onthoni‬ - ‪Google Scholar‬

Journal of Diabetes Investigation, 2024. 2024. Elucidating the Epigenetic Landscape of Type 2 Diabetes: A Multi-Omics Analysis Revealing Novel CpG Sites and ...

Epigenetics of the Pathogenesis and Complications of Type 2 ...

Epigenetics of type 2 diabetes mellitus (T2DM) has widened our knowledge of various aspects of the disease. The aim of this review is to ...

Epigenetics of diabetes type 2 - Wikipedia

In recent years it has become apparent that the environment and underlying mechanisms affect gene expression and the genome outside of the central dogma of ...

Editorial Metabolic Control of Stemness and ... - Minerva Access

changes to the epigenetic landscape, casting light on the ... demonstrate a clear and biologically relevant effect of type 2 diabetes (T2D) ... In addition, by ...

Targeting the epigenetic marks in type 2 diabetes mellitus: will epige

The epigenetic mechanisms in T2DM mainly consist of DNA methylation, histone modifications and regulation by noncoding RNAs (ncRNAs). For ...

Changes in Mitochondrial Epigenome in Type 2 Diabetes Mellitus

This suggests that D-loop methylation does regulate mtDNA gene expression in T2DM. These findings indicate that mitochondrial epigenetics does ...