Eph receptor signaling complexes in the plasma membrane

The EphrinA ligands (A1-A6) are tethered to the plasma membrane by a GPI anchor and preferentially bind EphA (1-10) receptors. The EphrinB ligands (B1-B3), ...

EPHA2 - Ephrin type-A receptor 2 - Homo sapiens (Human) - UniProt

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent ...

Roles of Eph/ephrin bidirectional signaling in central nervous ...

Eph receptors are activated when bound to membrane-combined ephrin ligands. A total of nine EphA receptors preferentially bind to five ...

Ephrins and their Eph receptors: multitalented directors of embryonic ...

Type A ephrins are attached to the cell membrane with a GPI linkage. Type B ephrins have transmembrane and cytoplasmic domains. Type A Eph receptors are more ...

Expression profile of Eph receptors and ephrin ligands in human ...

Eph receptors and ephrin ligands represent the largest family of receptor tyrosine kinases. Beyond their well-defined meaning in developmental processes, ...

Elevated protein tyrosine phosphatase activity provokes Eph/ephrin ...

Abstract. Signaling by Eph receptors and cell-surface ephrin ligands modulates adhesive cell properties and thereby coordinates cell movement and positioni.

Spatially modulated ephrinA1:EphA2 signaling increases local ...

Eph receptors and ephrin ligands form juxtacrine signaling complexes in the intercellular interface. Among all 16 Eph receptors, EphA2 is ...

PTP-PEST controls EphA3 activation and ephrin-induced ...

Eph receptors and their corresponding membrane-bound ephrin ligands regulate cell positioning and establish tissue patterns during embryonic and oncogenic ...

Eph receptor signaling and ephrins - University of Minnesota

The Eph receptors are the largest of the RTK families. Like other RTKs, they transduce signals from the cell exterior to the interior through ligand-induced ...

EPH receptor signaling as a novel therapeutic target in NF2 ...

Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2 ... , et al. Regulation of mTOR complex ...

Eph receptors and ephrins in cancer - Cell Signaling Networks

adhesive Eph–ephrin complexes from cell contact sites through an unusual ... rounding plasma membranes, into the receptor- or ephrin-expressing cell5 ...

Specific Eph Receptor-Cytoplasmic Effector Signaling Mediated by ...

Therefore, the cytoplasmic domains of Eph receptors must be able to engage different intracellular effectors in response to ephrin ligands. How ...

Paradoxes of the EphB1 receptor in malignant brain tumors

Increasing evidence shows that Eph/ephrin signaling regulates cell migration, adhesion, morphological changes, differentiation, proliferation ...

Ephrins and their Receptors: Binding versus Biology

The heterotetramers are further arranged into higher-order multi- meric complexes. Recent studies suggest that the recruitment of. Eph receptors into signaling ...

EphA2/Ephrin-A1 Signaling Complexes Restrict Corneal Epithelial ...

Although Eph receptors and ephrins have been most extensively studied in the context of embryonic development and tumor progression, these juxtamembrane ...

Structural and Functional Insights into the Transmembrane Domain ...

Identification of several characteristic dimerization motifs in the TM region sequences of Eph receptors indicates that TMD associations in the plasma membrane ...

Probing the effect of clustering on EphA2 receptor signaling ... - eLife

Clustering of ligand:receptor complexes on the cell membrane is widely presumed to have functional consequences for subsequent signal ...

The Eph/ephrin signaling system in cell positioning - UCSF

The Eph receptor tyrosine kinases were first identified based on their overexpression in human carcinoma (Hirai et al., 1987), and were later ...

Ligand recognition by A‐class Eph receptors: crystal structures of ...

The Eph receptors and their ephrin ligands control a diverse array of cell–cell interactions in the nervous and vascular systems (Himanen & Nikolov, 2003; ...

Concurrent Binding of Anti-EphA3 Antibody and Ephrin-A5 Amplifies ...

Abstract. The Eph receptor tyrosine kinases and their membrane-bound ephrin ligands form a unique cell-cell contact–mediated system for ...