GD2 CAR T Cells in Diffuse Intrinsic Pontine Gliomas

GD2 CAR-T cells in combination with Nivolumab exhibit enhanced ...

As demonstrated in Majzner's research, diffuse intrinsic pontine glioma ... GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas. Nature, 603 ...

GD2-specific CAR-T cells can be manufactured from peripheral ...

GD2-specific CAR-T cells can be manufactured from peripheral blood of patients with glioblastoma (GBM) and diffuse intrinsic pontine glioma (DIPG) and have ...

GD2-targeting CAR-T cells enhanced by transgenic IL-15 ... - bioRxiv

The commonest, most lethal form of childhood brain cancer is diffuse intrinsic pontine glioma (DIPG), the major subset of a broader group of ...

Safety and antitumor activity of GD2-Specific 4SCAR-T cells in ...

In brain tumors, GD2 is enriched on the tumor surface of 80% of diffuse intrinsic pontine glioma (DIPG) [19]. Functionally, GD2 exhibits cancer ...

Trial | NCT04196413 - Clinical Drug Experience Knowledgebase

GD2 CAR T Cells in Diffuse Intrinsic Pontine Gliomas(DIPG) & Spinal Diffuse Midline Glioma(DMG) ... The primary purpose of this study is to test whether GD2-CAR T ...

Research Update: Dual IGF1R/IR inhibitors in combination with GD2 ...

Diffuse midline gliomas (DMG) H3K27M-mutant, including diffuse intrinsic ... to screen 42 kinase inhibitors in combination with GD2-CAR T-cells.

Intraventricular B7-H3 CAR T Cells for Diffuse Intrinsic Pontine Glioma

This first report of repeatedly dosed intracranial B7-H3 chimeric antigen receptor (CAR) T cells for patients with DIPG includes preclinical efficacy, ...

Phase I Trial of GD2.CART Cells Augmented With Constitutive ...

... diffuse intrinsic pontine glioma. Cancer Cell 32:520-537.e5, 2017. 29. Hoffman LM, Veldhuijzen van Zanten SEM, Colditz N, et al: Clinical ...

Erratum to anti-GD2 CAR T cells could prove transformative for H3 ...

Erratum to anti-GD2 CAR T cells could prove transformative for H3-K27M+ diffuse midline gliomas. ... DIPG, diffuse intrinsic pontine glioma. The word “CAR-T” in ...

Potent antitumor efficacy of anti-GD2 CAR T cells in H3-K27M<

Diffuse intrinsic pontine glioma (DIPG) and other diffuse midline gliomas (DMGs) with mutated histone H3 K27M (H3-K27M)1-5 are aggressive and universally ...

GD2 is a target for immunotherapy in DIPG a, Top 68 antigens ...

Some studies explored the targeting of GD2 in diffuse intrinsic pontine glioma ... 36 Pre-clinical and efficacy trials are also looking into CAR-T cell therapy ...

A New Era in Brain Cancer Treatment: GD2-CAR T Cell Therapy ...

Gliomas with the H3K27M mutation, particularly diffuse midline gliomas (DMGs) and diffuse intrinsic pontine gliomas (DIPG), are among the ...

Sequential intravenous and intracerebroventricular GD2-CAR T-cell ...

Sequential intravenous and intracerebroventricular GD2-CAR T-cell therapy for H3K27M-mutated diffuse midline gliomas ... pontine (DIPG) or ...

CAR T cell therapy for pediatric central nervous system tumors

... T cell immunotherapy is an effective treatment for diffuse intrinsic pontine glioma. ... GD2 CAR T cells in H3–K27M(+) diffuse midline gliomas.

CAR T-Cell Therapy Shows Efficacy in Young Patients with ...

... diffuse intrinsic pontine glioma, or DIPG. The immune-cell therapy ... GD2-CAR T cells for H3K27M+ diffuse midline gliomas.” Of the 11 ...

Targeting of GD2 as a novel treatment for diffuse intrinsic pontine ...

anti-GD2 chimeric antigen receptor (CAR) T cell therapy in DIPGs has ... We are searching antibodies for surface antigens specific to glioma cell, and GD2 came up ...

C7R-GD2.CAR T Cells for Patients With GD2-expressing Brain ...

This study is for patients with diffuse midline glioma, high grade glioma, diffuse intrinsic pontine glioma, medulloblastoma, or another rare brain cancer that ...

Targeting of the alphav beta3 integrin complex by CAR-T cells leads ...

Background Diffuse intrinsic pontine glioma (DIPG) and glioblastoma (GBM) are two highly aggressive and generally incurable gliomas with little therapeutic ...

Engineering Enhanced GD2 CAR T-Cells to Overcome DIPG ...

The proposal builds on our experience treating children with diffuse intrinsic pontine glioma (DIPG) and other diffuse midline gliomas (DMG) ...

Current immunotherapeutic approaches to diffuse intrinsic pontine ...

... GD2 CAR T cells in H3-K27M(+) diffuse midline gliomas. ... Anti-tumor efficacy of anti-GD2 CAR NK-92 cells in diffuse intrinsic pontine gliomas.