- FGF21 protects against hepatic lipotoxicity and macrophage ...🔍
- Functions of two distinct Kupffer cells in the liver🔍
- Non|alcoholic fatty liver disease🔍
- Understanding Macrophage Complexity in Metabolic Dysfunction ...🔍
- Macrophage Scavenger Receptor 1 mediates lipid|induced ...🔍
- Metabolic Inflammation—A Role for Hepatic Inflammatory Pathways ...🔍
- Fructose as a key player in the development of fatty liver disease🔍
- HIF|2α drives hepatic Kupffer cell death and proinflammatory ...🔍
Hepatic Macrophage as a Key Player in Fatty Liver Disease
FGF21 protects against hepatic lipotoxicity and macrophage ... - eLife
These revealed that both NAFLD activity and liver fibrosis were associated with both CD36hi ResKCs, CD36hi MoKCs, and CD9hi MoKCs (Figure 6— ...
Functions of two distinct Kupffer cells in the liver
Increasing evidence shows that targeting hepatic macrophages can prevent and reverse non-alcoholic fatty liver disease (NAFLD), with a new suggested name ...
Non-alcoholic fatty liver disease: pathophysiological concepts and ...
Whereas simple hepatic steatosis is the most common disease manifestation, a more progressive disease course characterized by liver fibrosis and inflammation ( ...
Understanding Macrophage Complexity in Metabolic Dysfunction ...
Hepatic macrophages are a crucial cellular component of the liver and play important roles in liver function, contributing significantly to tissue ...
Macrophage Scavenger Receptor 1 mediates lipid-induced ...
Obesity-associated inflammation is a key player in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). However, the exact mechanisms remain ...
Metabolic Inflammation—A Role for Hepatic Inflammatory Pathways ...
Nonalcoholic fatty liver disease (NAFLD) is a global and growing health concern. Emerging evidence points toward metabolic inflammation as a key process in ...
Fructose as a key player in the development of fatty liver disease
Hepatic de novo lipogenesis (fatty acid and triglyceride synthesis) is increased in patients with NAFLD. Stable-isotope studies showed that ...
HIF-2α drives hepatic Kupffer cell death and proinflammatory ...
Evidence indicates that proinflammatory macrophage activation is key for the transition from simple fatty liver to advanced NAFLD (6, 7). In ...
The Role of Innate Immune Cells in Nonalcoholic Fatty Liver Disease
Cells of innate immunity, such as neutrophils or macrophages, are central regulators of NASH-related inflammation.
Kupffer cells: increasingly significant role in nonalcoholic fatty liver ...
Non-alcoholic fatty liver disease (NAFLD) is considered to be a manifestation of liver metabolic damage and is related to insulin resistance and genetic ...
Mitochondrial oxidative injury: a key player in nonalcoholic fatty liver ...
Convincing evidence has emerged that hepatic mitochondrial dysfunction precedes the development of NAFLD and insulin resistance (88), and these findings also ...
Macrophages and scavenger receptors in obesity‐associated non ...
Non-alcoholic fatty liver disease is the hepatic manifestation of metabolic syndrome and the most common chronic liver disease worldwide. It is a ...
Therapeutic Targeting of Hepatic Macrophages - SpringerLink
The liver also plays an important role in maintaining liver immune homeostasis and employs different mechanisms to suppress immune system and ...
Kupffer Cells in Non-alcoholic Fatty Liver Disease: Friend or Foe?
In a marginal-copper high-fructose diet (CuMF) rats, Kupffer cell ablation decreases hepatic triglyceride accumulation and plasma macrophage ...
Targeting hepatic kisspeptin receptors and nonalcoholic fatty liver ...
It was observed that under HFD conditions, livers from LKO mice showed a significant upregulation of the expression of all genes (Figure 2A), ...
Macrophages and hepatocellular carcinoma - Cell & Bioscience
Macrophages play a crucial role in chronic liver inflammation. The tumor microenvironment plays a key role in the progression of HCC.
Crosstalk between liver macrophages and gut microbiota
Crosstalk between hepatic macrophages and gut microbiota is an important component of liver inflammation and related liver diseases.
Macrophages in obesity and non-alcoholic fatty liver disease - CORE
the liver that perform a range of metabolic func- tions in homeostasis and disease. Hepatic macrophages are central players in the progres-.
Role of gp91 phox in hepatic macrophage programming and ...
Macrophages (MΦs) have emerged as a critical player and therapeutic target in many chronic inflammatory diseases3 through their many proinflammatory and anti‐ ...
Novel Action of Carotenoids on Non-Alcoholic Fatty Liver Disease
NAFLD is considered a hepatic manifestation of metabolic syndrome; however, mechanisms underlying the onset and progression of NAFLD are still unclear. Resident ...