Identification of four novel associations for B|cell acute ...

Multiplexed Digital Detection of B-Cell Acute Lymphoblastic ...

Chromosomal rearrangements resulting in fusion transcripts have been reported in precursor B-cell acute lymphoblastic leukemia (B-ALL).

A two-stage genome-wide association study to identify novel genetic ...

Genetic variants associated with acute side effects of radiotherapy in nasopharyngeal carcinoma (NPC) remain largely unknown.

TARGET Acute Lymphoblastic Leukemia (ALL)

... B-cell ALL. The TARGET ALL Phase II project has produced ... ) Identification of novel cluster groups in pediatric high-risk B-precursor acute ...

Genomic Profiling of Adult and Pediatric B-cell Acute Lymphoblastic ...

Eight gene expression subgroups associated with characteristic genetic abnormalities were identified, including leukemia with MEF2D and ZNF384 fusions in two ...

MD-ALL: an integrative platform for molecular diagnosis of B-acute ...

With the application of transcriptome sequencing (RNA sequencing [RNA-seq]), multiple novel subtypes have been identified, which lead to an ...

Clinical Significance of Novel Subtypes of Acute Lymphoblastic ...

Among the 16 B-cell ALL (B-ALL) and 8 T-cell ALL subtypes identified by next-generation sequencing, ETV6–RUNX1, high-hyperdiploid, and DUX4-rearranged B-ALL had ...

Acute Lymphoblastic Leukemia (ALL)

B-ALL s the most common subtype and occurs in immature cells that would normally develop into B-cells, important for immunity. B-ALL is more common in children, ...

Expression of BCL6 in paediatric B-cell acute lymphoblastic ...

B-cell lineage acute lymphoblastic leukaemia (B-ALL) is the most common paediatric malignancy. Transcription factor B-cell lymphoma 6 (BCL6) ...

Genome-Wide Association Analyses Identify Variants in IRF4 ...

... B., Law, P. J., et al. (2019). Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk. Nat. Commun. 10:5348. doi: 10.1038 ...

Identification of a novel susceptibility locus at 16q23.1 associated ...

Recently, genome-wide association studies (GWAS) have identified several susceptibility loci for childhood acute lymphoblastic leukemia (ALL) in population.

New targets for therapy: antigen identification in adults with B-cell ...

ADC: Antibody–drug conjugates ; ALL: Acute lymphoblastic leukaemia ; AML: Acute myeloid leukaemia ; BiTE: Bispecific T-cell engager ; BMX: Bone ...

Association of Genetic Ancestry With the Molecular Subtypes and ...

... identified many novel subtypes previously loosely classified as “B other. ... B-cell acute lymphoblastic leukemia: a report from the COG.

Genome-wide association analyses identify variants in IRF4 ...

Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk. ... IRF-4 functions as a tumor suppressor in early B-cell ...

Oncogenic lesions and molecular subtypes in adults with B‐cell ...

The distribution of B-cell acute lymphoblastic leukemia (B-ALL) molecular subtypes is dependent on age. Recent advances in sequencing ...

A childhood acute lymphoblastic leukemia genome-wide ... - CORE

leukemia genome-wide association study identifies novel ... Replication analysis confirms the association of ARID5B with childhood B-cell acute ...

Genetic Basis of Acute Lymphoblastic Leukemia

... cell acute lymphoblastic leukemia; BCP-ALL, B-cell precursor acute ... Identification of novel cluster groups in pediatric high- risk B ...

Acute lymphoblastic leukemia - Wikipedia

ALL - L2, T cell or pre-B cell, Large and heterogeneous (varied) cells ; ALL - L3, B cell, Large and varied cells with vacuoles, Mature B-cell ALL also named ...

Transcriptional landscape of B cell precursor acute lymphoblastic ...

Most B cell precursor acute lymphoblastic leukemia (BCP ALL) can be classified into known major genetic subtypes, while a substantial proportion ...

Genomewide Association Study of Severe Covid-19 with ...

Conclusions. We identified a 3p21.31 gene cluster as a genetic susceptibility locus in patients with Covid-19 with respiratory failure and ...

Genetics of Acute Lymphoblastic Leukemia - IntechOpen

Acute lymphoblastic leukemia (ALL) is mainly a disease of childhood that arises from recurrent genetic alterations that block precursor B- and T-cell ...