Identification of nine genes as novel susceptibility loci for early‑onset ...

Young-Onset Type 2 Diabetes Families Are the Major Contributors ...

In the previously published unstratified analysis, evidence for linkage (logarithm of odds [LOD] >1.18) was found at seven loci. The LOD scores ...

[PDF] Identification of novel susceptibility loci for inflammatory bowel ...

... susceptibility loci contributing to the genetic risk for CD and UC. The ... susceptibility in families with early-onset disease. Expand. 534 Citations.

Mapping the genetic landscape of early-onset Alzheimer's disease ...

In eight families, we identified a pathogenic variant, including the genes APP, PSEN1, SORL1, and an unexpected GRN frameshift variant. APOE-ε4 ...

1 Identification of 16 novel Alzheimer's disease susceptibility loci ...

identified nine new rare variant loci showing genome-wide significant association with ... genetic similarity among any first-degree ...

The 330 risk loci known for systemic lupus erythematosus (SLE)

At the beginning of 2023, we found 330 published genetic risk loci that satisfy the stringent requirement of association at p ≤ 5 × 10−8 in at least one study.

A Genome Scan Using a Novel Genetic Cross Identifies New ...

We have identified four new PGIA-linked QTLs (Pgia13 through Pgia16) and confirmed two (Pgia5, Pgia10) from our previous study. All new MHC-independent QTLs ...

Genome sequence analyses identify novel risk loci for multiple ...

The most associated SNP was rs242557, located within the first intron of the MAPT gene on the long arm of chromosome 17, with a p value of 0.049, which is far ...

Identification of novel susceptibility loci for inflammatory bowel ...

The number of affected relative pairs undergoing the initial, genome-wide screen in these studies suggests that additional loci possibly might be identified ...

Genome‐Wide Association Meta‐Analysis Reveals Novel Juvenile ...

GWAS = genome-wide association study. NEWLY IDENTIFIED JIA SUSCEPTIBILITY LOCI. 2229. Page 9. Other mechanisms are also probable. For ...

Identification of Susceptibility Loci for Skin Disease in a Murine ...

In addition, a locus on chromosome 6 that promoted earlier onset of the disease was identified in the most severely affected mice. For the first time, we have ...

Genetic loci associated with Alzheimer's disease - Europe PMC Article

FULL TEXT Abstract: The article by Lambert et al. reports the identification of 11 novel susceptibility loci for late-onset Alzheimer's disease.

Identification of Novel Alzheimer's Disease Loci Using Sex-Specific ...

Early-onset familial AD. (monogenic) is caused by rare fully penetrant mutations in APP, PSEN1, PSEN2 genes2. The more prevalent form, late- ...

Identification of Novel Breast Cancer Risk Loci - AACR Journals

The protein sequences of the three genes JAK2, NOTCH3, and HIF1A were retrieved from the NCBI protein database and were used for the analysis of protein ...

A Genome-Wide Association Study Identifies Novel and Functionally ...

This is one of the first GWAS in an infectious disease. We have identified novel, plausible, and functionally related variants associated with KD susceptibility ...

Identifying 31 novel breast cancer susceptibility loci using data from ...

Common genetic variants in 183 loci have been identified in relation to breast cancer risk in genome-wide association studies (GWAS). These risk ...

Identification of Novel T1D Risk Loci and Their Association With Age ...

The high genetic correlation of different T1D subgroups indicated that these cases can be combined for analysis. Association analysis revealed ...

Identification of 13 novel susceptibility loci for early-onset myocardial ...

The NHGRI-EBI GWAS Catalog: a curated collection of all published genome-wide association studies, produced by a collaboration between EMBL-EBI and NHGRI.

Genetic meta-analysis identifies 9 novel loci and functional ... - bioRxiv

APOE is the strongest genetic risk locus for late-onset AD, ... test for a causal effect of a late-onset disease on an early onset disease).

Identification and Replication of Forty-Six Novel Risk Loci for ...

Genome-wide Analysis Identifies Novel Gallstone-susceptibility Loci Including Genes Regulating Gastrointestinal Motility ... ABCB4 mutations are a cause of early- ...

佐久間淳 (Jun Sakuma) - Identification of nine genes as novel ...

Identification of nine genes as novel susceptibility loci for early-onset ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage. EUROPEAN ...