Mathematical Modeling in Circadian Rhythmicity

Analytic and Modeling Unit - Division of Sleep Medicine

Our group develops and applies new mathematical analytic techniques to circadian rhythms, hormone, actigraphy and sleep data.

(Too Many) Mathematical Models of Circadian Clocks (?) - CONICET

ological approaches to the numerical aspects of circadian rhythms. We also hope to help the novice clock model maker by discussing some of the fundamental ...

A Mathematical Model to Characterize the Role of Light Adaptation ...

In response to a light stimulus, the mammalian circadian clock first dramatically increases the expression of Per1 mRNA, and then drops to a baseline even when ...

Mathematical modeling of mammalian circadian clocks affecting ...

This circadian control of physiology is intrinsically driven by a cell-autonomous clock gene network present in almost all cells of the body that drives ...

Mathematical modeling of circadian rhythms

Related reading · Circadian Rhythms, Sleep, and the Autonomic Nervous System · Comparative analysis of circadian rhythms of hemodynamics and physical activity.

On the need for mathematical models for integration of sleep ...

15. Phillips, A.J. ∙ Chen, P.Y. ∙ Robinson, P.A. ... This integration is crucial because considering circadian rhythmicity and sleep homeostasis ...

A stochastic oscillator model simulates the entrainment of vertebrate ...

The circadian clock is a cellular mechanism that synchronizes various biological processes with respect to the time of the day.

Mathematical modeling for translational rese - EurekAlert!

A circadian rhythm is a 24-hour cycle in the physiological processes of living creatures, including humans. A biological clock in the ...

Mathematical Modeling of Circadian Gene Expression in ...

Circadian rhythms in mammals are self-sustained repeating activities driven by the circadian gene expression in cells, which is regulated at ...

A mathematical model of circadian rhythms and dopamine

Our mathematical model can be used for further investigations of the effects of the mammalian circadian clock on the dopaminergic system. The model can also be ...

Modeling circadian clocks: From equations to oscillations

This paper reviews some mathematical models for circadian clocks, ranging from abstract, phenomenological models to the most detailed molecular models, ...

Mathematical Modeling of Dynamics of Gene Expression Levels ...

The present study focuses on mathematical modeling of the dynamics of gene expression levels of circadian rhythm. All living organisms exhibit daily ...

Mathematical models may help shed light on body clock disruptions

Frequent and sustained disturbances to the body's circadian rhythms eliminated the shared rhythm, implying a weakening of the signals ...

A Simple Model of Circadian Rhythms Based on Dimerization and ...

These ideas can be expressed in simple mathematical form (phase plane portraits), and the model accounts naturally for several hallmarks of circadian rhythms, ...

Biophysical and Mathematical Models of Circadian Rhythms

Others think that the organism may contain a much more subtle clock of superior precision or that the environment may contribute a “Zeitgeber” through more ...

Mathematical Modeling of Phosphorylation in Circadian Clocks from ...

... circadian rhythms. [more]. Subjects. mathematical modeling. mammalian circadian clock. protein phosphorylation. interval timer. cyanobacterial circadian clock ...

Mathematical modeling informs the impact of changes in circadian ...

Disruption of circadian rhythms has been associated with metabolic syndromes, including obesity and diabetes. A variety of metabolic activities are under ...

Mathematical modeling for translational research of new CRSD ...

Mathematicians' new modeling has identified major sources of interspecies and inter-individual variations in the clinical efficacy of a ...

Circadian Rhythm and Pain: Mathematical Model based on ...

In this sense, this work aims to study a mathematical and computational model based on multiagent simulation that simulates the synchronization ...

Modeling Biological Rhythms in Cell Populations

In tissues, cell proliferation is driven by the circadian clock, which modulates the progression through the cell cycle along the day. The circadian clock shows ...