Mechanisms for Size|Dependent Protein Segregation at Immune ...

MAL Protein Controls Protein Sorting at the Supramolecular ... - OUCI

The mechanism of protein sorting to the SMAC subdomains is still unknown. MAL forms part of the machinery for protein targeting to the plasma membrane by ...

A Novel Size-Based Sorting Mechanism of Pinocytic Luminal ...

Microglia are the resident immune cells in the CNS and play diverse roles in the maintenance of CNS homeostasis. Recent studies have.

Segregation of HLA-C from ICAM-1 at NK Cell Immune Synapses Is ...

Immune cell interactions sometimes trigger the segregation of proteins into micrometer-scale domains at the intercellular contact, thereby ...

Vacuolar protein sorting 35 - Society for Developmental Biology

In previous studies, it was shown that the localization of aPKC and Par6 was dependent on Crb. To test whether loss of retromer phenocopies the ...

Protein sorting by lipid phase-like domains supports ... - eLife

When BCR is clustered, the effect on downstream signaling depends on the size and stability of the resulting domain, which sets the level of ...

Self‐organization of apical membrane protein sorting in epithelial cells

Despite these efforts, the rules guiding apical sorting are poorly understood and remain controversial. Here, we consider mechanisms of apical ...

Cytokine release from innate immune cells - ASH Publications

SNARE complexes and SNARE-interacting proteins mediate membrane fusion at successive transport steps from the Golgi to the cell membrane to facilitate the ...

Arf6-independent GPI-anchored Protein-enriched Early Endosomal ...

Dominant-Negative Rab5 Inhibits Fusion between GEECs and Sorting Endosomes. The mechanism of EEA1 recruitment on sorting endosomes is dependent on both active ...

Sorting nexin 27–dependent regulation of Lck and CD4 tunes the ...

Defects in SNX27 levels also limit basal expression of CD4. The association between Lck and CD4 represents the first example of how immune receptors employ ...

Adaptor proteins involved in polarized sorting | Journal of Cell Biology

The clathrin-associated adaptor protein 1 (AP-1) complex plays a preeminent role in this process, although other adaptors and coat proteins, ...

Viral Membrane Fusion Proteins and RNA Sorting Mechanisms for ...

All these signals trigger the thermodynamically favored process of the refolding of the fusion protein into a stable final post-fusion form [33]. In the first ...

Arginine-dependent immune responses | Cellular and Molecular ...

In addition to being a building block for protein synthesis, arginine serves as a substrate for distinct metabolic pathways that profoundly ...

Mechanisms regulating the sorting of soluble lysosomal proteins

Abstract. Lysosomes are key regulators of many fundamental cellular processes such as metabolism, autophagy, immune response, cell signalling and plasma.

structure and DNA binding of the Soj dimer — a conserved ...

Here, we show that Soj undergoes ATP‐dependent dimerisation in solution and forms nucleoprotein filaments with DNA.

Simulation of receptor triggering by kinetic segregation shows role of ...

... Size Differences Explain Protein Segregation at Immune Synapses. PLoS ... How a protein searches for its site on DNA: the mechanism of facilitated ...

Phase separation in immune signalling. - Abstract - Europe PMC

Alternatively, recent studies have shown that multivalent interactions between membrane-proximal proteins can drive the formation of liquid-like ...

A putative RNA-interference-based immune system in prokaryotes

Given our hypothesis that RAMPs are size-specific psiRNA-binding proteins ... A very similar mechanism involving the RNA-dependent RNA polymerase ...

KEGG PATHWAY Database

2.3 Folding, sorting and degradation. 03060: Protein export; 04141 N: Protein processing in endoplasmic reticulum; 04130: SNARE interactions in ...

Size Matters: Protein Segregation at Membrane Interfaces

The simulations indicated that nonbinding proteins that are more than 2nm taller than membrane gap are excluded. When simulating the effects of ...

Tom Rapoport (Harvard, HHMI) 1: Organelle Biosynthesis and ...

https://www.ibiology.org/cell-biology/protein-sorting Eukaryotic cells have many different membrane-bound organelles with distinct functions ...