New Insights on NLRP3 Inflammasome

Pharmacological Inhibition of the NLRP3 Inflammasome: Structure ...

New structural and mechanistic insights into NLRP3 activation and inhibitor-NLRP3 interactions would aid in the rational design and ...

The cardiac glycoside ouabain activates NLRP3 inflammasomes ...

Our findings demonstrate that cardiac glycosides promote cardiac inflammation and dysfunction through NLRP3 inflammasomes and provide new insights into the ...

New insights in caspase-11 functions in noncanonical ... - HAL

Recent data using Gram-negative bacteria suggests a role for caspase-11 not only in NLRP3 inflammasome activation but also in a caspase-1- and ...

Prof. Hao Wu on X: "The NLRP3 inflammasome! Jianing (Kara) Fu of ...

just published her brand new review on the structural mechanisms of this inflammasome, with lots of new insights!

Structure, Molecular Activation, and Inhibitor-NLRP3 Interaction

... NLRP3 Inflammasome. Inhibitors: Design, Synthesis ... binding of NLRP3 generated new insights into its mode of action and inhibitor-NLRP3.

NLRP3 Inflammasome Inhibitors and AI-Driven Predictive Health ...

structure point of view, aiming to provide new insights for the further development of clin. drugs for NLRP3 inflammasome-mediated diseases.

Role of NLRP3 inflammasome in inflammatory bowel diseases

... NLRP3 inflammasome, will provide new insights into the field of IBD pathogenesis. ROLE OF NLRP3 INFLAMMASOME IN MUCOSAL IMMUNE RESPONSES.

Ventus Therapeutics Announces Publication in Journal of ...

New insights into the structure and mechanism of these proteins may ... inflammasome receptors and is integral in the formation of the NLRP3 inflammasome.

New Insights into the Mechanisms of Pyroptosis and Implications for ...

In inflammation, pathways above activate NLRP3 inflammasome and caspase-1 and induce secretion of IL-18 and IL-1β. PKC, protein kinase C; AGE, ...

A new lead to NLRP3 inhibition | Journal of Experimental Medicine

Insight into the signaling mechanisms by which inflammasomes respond to particular DAMPs and PAMPs offers new entry points to block caspase ...

Interactions between NLRP3 inflammasome and glycolysis in ...

Interactions between NLRP3 inflammasome and glycolysis in macrophages: New insights into chronic inflammation pathogenesis. Abstract. NLRP3 inflammasome ...

New insights into the regulatory roles of glutathione in NLRP3 ...

As a result of these findings, GSH was assigned a central role in influencing the activation of the NLRP3 inflammasome. To expand on our recent ...

NLRP3 Inflammasome Activation Mediates Zika Virus–Associated ...

... NLRP3 inflammasome–mediated interleukin 1β production via interaction with NLRP3 and gen. ... These findings offer new insights into inflammasome-mediated ...

Basic/Translational Symposium: New Insights Connecting ...

Basic/Translational Symposium: New Insights Connecting Inflammation and Bone Resorption ... NLRP3 inflammasome. Donate · Join/Renew · Get Involved ...

review - The American Journal of Pathology

New Insights into Mechanisms Controlling the NLRP3. Inflammasome and Its Role in Lung Disease. Dominic De Nardo,* Christine M. De Nardo,* and ...

Mechanisms of inflammasome activation: recent advances and ...

This review outlines these new insights in inflammasome research and discusses areas that warrant further exploration. Keywords. inflammasomes ...

NodThera Announces Positive Phase 1 Study Readouts for the ...

NodThera is a clinical-stage biotechnology company developing a new class of potent and selective NLRP3 inflammasome inhibitors for the ...

Interactions of the NLRP3 Inflammasome Complex - IRL @ UMSL

... regarding how Aβ activates the NLRP3 inflammasome and also offer new perspectives relating to the actual structure of active caspase-1.

Molecular Activation of NLRP3 Inflammasome by Particles and ...

Recent structural studies provided new insights into the structures of inactive NLRP3 and the assembly of the NLRP3 inflammasome. Both ...

Kate Schroder - Inflammasome signalling - YouTube

Kate Schroder - Inflammasome signalling: from fundamental biology to new therapeutics ... NLRP3 Inflammasome activation. F. Hoss•27K views.