PGE2 /EP4 antagonism enhances tumor chemosensitivity by ...

Stem Cells Translational Medicine. 2019 Jul;8(7):707-723. 2018-09, PGE2 /EP4 antagonism enhances tumor chemosensitivity by inducing ...

[PDF] Cytosolic phospholipase A2 activation correlates with HER2 ...

Prostaglandin E receptor EP4 antagonism inhibits breast cancer metastasis. · Biology, Medicine. Cancer research · 2006.

NK4 Gene Expression Enhances 5-Fluorouracil-induced Apoptosis ...

: Colon carcinoma cell growth is associated with prostaglandin E2/EP4 receptor-evoked ERK activation. ... cancer cells resulting in enhanced chemosensitivity.

Definition of EP4 antagonist ONO-4578 - NCI Drug Dictionary

EP4, a prostanoid receptor, is a G protein-coupled receptor that is expressed in certain types of cancers; it promotes tumor cell proliferation and invasion.