Patient|derived head and neck cancer organoids allow treatment ...

Correlation of the treatment sensitivity of patient- derived organoids ...

In this study, we aim to assess whether we can generate PDOs from head and neck squamous cell carcinoma (HNSCC) samples and whether PDOs can be ...

Patient-Derived Head and Neck Cancer Organoids Recapitulate ...

Targeted PDT, using a photosensitizer conjugated to tumor-targeting molecules, has been explored as a more selective cancer therapy. Organoids are self- ...

ORGAVADS: establishment of tumor organoids from head and ... - HAL

Background Radiotherapy is one of the cornerstones of the treatment of Head and Neck Squamous Cell Carcinomas ... Patient‑derived cancer organoids ...

Using Patient-Derived Organoids, Oncologists Can Predict a ...

“In head and neck cancer, utilizing patient-derived organoids to help predict response to non-surgical therapies may help with decision-making ...

Head and neck cancer organoids as a step towards personalised ...

Researchers from the Organoid group (Hubrecht Institute) and UMC Utrecht have developed a biobank with organoids derived from patients with ...

Organoids as a tool in drug discovery and patient-specific therapy ...

Organoids more accurately reflect tumor microenvironment than traditional models. Millen et al. demonstrated organoids replicated from patient tissues may ...

Establishment of patient-derived cancer organoids for drug ...

We also provide an in-depth protocol for the generation of head and neck squamous cell carcinoma organoids and their subsequent use in semi-automated therapy ...

Patient-Derived Organoids: Promises, Hurdles and Potential Clinical ...

Tissue and liquid biopsies allow molecular profiling of cancers, providing an important tool for the identification of tailored treatments.

The Role of Patient-Derived Tumor Organoids in Precision Medicine

Tumor organoids allow the testing of a wide variety of possible therapies, many of which might not be standard of care for the indication in ...

June 17: Testing therapies on mini-tumors of head and neck cancer

Head and neck cancer is an aggressive type of cancer that often grows back, despite patients undergoing harsh treatments.

Clinicopathological Factors as Predictors for Establishment of ...

Keywords Head and neck cancer · Patient derived organoids · Head and neck squamous cell carcinoma organoids · ... head and neck cancer organoids allow treatment ...

Hubrecht Institute and UMC Utrecht Develops Head and Neck ...

They used this biobank to validate known HNC biomarkers and found that treatment responses in the organoids matched those seen in patients. The ...

Patient-Derived Models Repository (PDMR)

The National Cancer Institute (NCI) is developing a national repository of Patient-Derived Models (PDMs) comprised of patient-derived xenografts (PDXs).

Genomic and single-cell characterization of patient-derived tumor ...

Head and Neck Squamous Cell Carcinoma (HNSCC) remains a significant health burden due to tumor heterogeneity and treatment resistance, ...

Personalized medicine: Testing therapies on mini-tumors of head ...

Head and neck cancer is an aggressive type of cancer that often recurs, despite patients undergoing harsh treatments.

Patient-derived organoids in human cancer: a platform for ...

In contrast to conventional models, tumor organoids offer an intuitive, dependable, and efficient in vitro research model by conserving the ...

Tumor Organoids :: DKTK

... head and neck cancer). PDTOs have also been established for several more ... Co-clinical trials have been initiated that link the treatment response in patients ...

Patient-derived three-dimensional culture techniques model tumor ...

Here, we review work that has been done using PDO and OTC models of HNSCC, which demonstrates that these 3D culture models capture in vivo tumor heterogeneity ...

Clinical translation of patient-derived tumour organoids- bottlenecks ...

In early-stage tumours, head and neck cancers are treated with radiation therapy as its sole therapy. Radiation therapy is also often used ...

Pancreatic cancer organoids recapitulate disease and allow ... - PNAS

We describe a biobank of patient-derived pancreatic cancer organoids, characterized by whole-genome DNA sequencing, RNA sequencing, and histology.