Senescence|Induced Vascular Remodeling Creates Therapeutic ...

rhACE2 Therapy Modifies Bleomycin-Induced Pulmonary ...

and SOD2 siRNA creates a PAH phenotype in vascular ... treatment could fill a necessary void in PH treatment by decreasing vascular remodeling.

Molecular Mechanisms Underlying Vascular Remodeling in ...

... vessels and stem cells in hypertension-induced vascular remodeling. ... therapeutic target for treating EC senescence. Yu et al. [41] ...

Effects of senescence on the tumour microenvironment and ...

Moreover, after doxorubicin treatment, senescent ECs in the thymus of a mouse model of B-cell lymphoma released IL-6, creating a peri-vascular ' ...

Cellular senescence impairs the reversibility of pulmonary arterial ...

... vascular remodeling, suggesting a potential therapeutic target for patients with PAH. ... remodeling that causes increased pulmonary ...

Amelioration of Tumor-promoting Microenvironment via Vascular ...

... treatment (8); thus, establishing the concept of eribulin-induced vascular remodeling. However, precise mechanisms have not fully investigated yet (9) ...

Senescence and aging: Causes, consequences, and therapeutic ...

-C. Chen. , et al. 2016 . BRD4 connects enhancer remodeling to senescence ... M.R.. Bennett . 2016 . Ageing induced vascular smooth muscle cell senescence in ...

The Quest to Define and Target Cellular Senescence in Cancer - eriba

Senescence-induced vascular remodeling creates therapeutic vulnerabilities in pancreas cancer. Cell 2020;181:424–41. 8. Wang C, Vegna S, Jin ...

Malignant cell-derived PlGF promotes normalization and remodeling ...

Thus, modulation of PlGF-induced vascular remodeling activity in the tumor environment may be crucial for development of therapeutic agents in combination with ...

Netrin 1 contributes to vascular remodeling in the subventricular ...

Vascular remodeling after LPC-induced demyelination of the CC. ... 3A-C). Fig. 3. Fig. 3. Effect of anti-VEGF treatment on blood vessel density ...

Extracellular matrix alterations in hypertensive vascular remodeling

... vascular remodeling into viable therapeutic strategies? ... Potential roles of plasminogen activator system in coronary vascular remodeling induced by long-term ...

Inflammation in injury-induced vascular remodelling

... makes it a potential candidate for ant-restenosis therapy. Furthermore, it was hypothesized that chemokines are involved in vascular remodeling, since they ...

miR-127-3p modulates inflammation in injury-driven vascular ...

miR-127-3p modulates inflammation in injury-driven vascular remodeling and cellular senescence in vascular smooth muscle cells ... Micro RNAs (miRs) are promising ...

Tumor necrosis factor inhibitors as novel therapeutic tools for ...

Vascular remodeling diseases (VRDs) are characterized by enhanced inflammation and proliferative and apoptosis-resistant vascular smooth muscle cells ...

Cardiac pericytes mediate the remodeling response to myocardial ...

Finally, genetic ablation of pericytes induced vascular leakage in ... These findings can provide essential information for therapies to promote ...

Rapamycin attenuates hypoxia-induced pulmonary vascular ...

... remodeling therapy in hypoxia-induced PAH. Methods ... Therapeutic effect of rapamycin after induction of pulmonary vascular remodeling.

Cellular senescence impairs the reversibility of pulmonary arterial ...

Cellular senescence was associated with late-stage, irreversible PAH and treatment with a senolytic could alter maladaptive vascular remodeling.

Senescence and cancer — role and therapeutic opportunities - OUCI

Neutrophil extracellular traps target senescent vasculature for tissue remodeling ... Senescence-induced vascular remodeling creates therapeutic vulnerabilities ...

Vascular Senescence in Cardiovascular and Metabolic Diseases.

... aging per se is linked with vascular remodeling that predisposes to cardiovascular disease. ... Therapies Targeting Senescent Cells for Cardiovascular and ...

Angina: Symptoms, Causes & Treatment - Cleveland Clinic

Stable angina (angina pectoris) is the most common type, and it's caused by coronary artery disease. ... construction sites). Family history of early heart ...

Health Topics - CDC

Find diseases and conditions; healthy living; workplace safety; environmental health; injury, violence and safety, global health and more.