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The mitochondrial mRNA|stabilizing protein SLIRP regulates ...


LRPPRC is necessary for polyadenylation and coordination of ...

The leucine‐rich pentatricopeptide repeat containing (LRPPRC) protein regulates mitochondrial mRNA stability ... SLIRP in mitochondrial RNA homeostasis.

LRPPRC-mediated folding of the mitochondrial transcriptome.

We show that LRPPRC, in complex with its protein partner SLIRP, binds throughout the mitochondrial transcriptome, with a preference for mRNAs, ...

Mechanisms and regulation of protein synthesis in mitochondria

LRPPRC/SLIRP suppresses PNPase-mediated mRNA decay and promotes polyadenylation in human mitochondria. ... SLIRP regulates the rate of mitochondrial protein ...

Mitochondrial transcription and translation: overview - Portland Press

... RNA-binding protein (SLIRP) [55]. ... C. et al. (. 2015. ) SLIRP Regulates the Rate of Mitochondrial Protein Synthesis and Protects LRPPRC from ...

Structural basis of mitochondrial translation - eLife

The study reveals a transacting protein module LRPPRC-SLIRP that delivers mt-mRNA to the mitoribosomal small subunit through a dedicated ...

Targeting Mitochondrial Protein Expression as a Future Approach ...

However, to the current knowledge, mitochondrial gene expression is predominantly regulated at post-transcriptional level through the modulation of mRNA ...

Human Mitochondrial RNA Processing and Modifications: Overview

... RNA-binding protein (SLIRP), forming the LRPPRC/SLIRP complex. This ... NLRX1 resides in mitochondrial RNA granules and regulates mitochondrial ...

Mitochondrial transcription and translation: overview - CORE

(2015) SLIRP Regulates the Rate of Mitochondrial Protein Synthesis and Protects. LRPPRC from Degradation. PLoS Genet. 11, e1005423, https ...

LRPPRC and SLIRP interact in a ribonucleoprotein complex that ...

... regulates posttranscriptional gene expression in mitochondria ... SLIRP, a stem-loop RNA-binding protein. Although this interaction ...

The Mitochondrial RNA-Binding Protein GRSF1 ... - CiteSeerX

To date, only two mitochon- drial mRNA-binding proteins have been extensively character- ized, LRPPRC (Mootha et al., 2003) and SLIRP (Baughman.

The Leucine-rich Pentatricopeptide Repeat-containing Protein ...

Background: LRPPRC regulates mitochondrial mRNA stability and was recently reported to also stimulate mammalian. mtDNA transcription. Results ...

Mitochondrial transcript maturation and its disorders

The LRPPRC-SLIRP complex regulates mt-mRNA stability and translation without directly associating with ribosomes or POLRMT (Ruzzenente et al ...

SLIRP, a Small SRA Binding Protein, Is a Nuclear Receptor ...

Our data demonstrate that SLIRP modulates NR transactiva- tion, suggest it may regulate mitochondrial function, and provide mechanistic insight ...

A novel protein encoded by circRsrc1 regulates mitochondrial ...

Mechanistically, Rsrc1-161aa directly interacts with mitochondrial protein C1qbp and enhances its binding activity to mitochondrial mRNAs, ...

The mt-mRNA-stabilizing protein LRPPRC regulates mitochondrial ...

The mt-mRNA-stabilizing protein LRPPRC regulates mitochondrial structure and function in skeletal muscle ; Langue: Anglais ; Date de publication: 31/12/2024.