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Carboplatin Dosing Accounting for the Renal and Hematologic ...


Carboplatin Dosing in Overweight and Obese Patients

Carboplatin dosage relies on glomerular filtration rate (GFR) and area under the curve (AUC). The Calvert formula is the preferred method to calculate the dose ...

Comparing carboplatin dose administered to the calculated dose ...

In Group A, cycle 2 dose reductions were made in 3 cases (8% and due to hematologic). In Group B, cycle 2 dose reductions were made in 12 cases. In 8 of these ...

dbl™ carboplatin injection

In patients with initial impaired renal function reduction of dosage of carboplatin may be ... Peripheral blood counts and renal function should be ...

Management of patients with end-stage renal disease undergoing ...

21. Calvert, A.H. ∙ Newell, D.R. ∙ Gumbrell, L.A. ... Carboplatin dosage: prospective evaluation of a simple formula based on renal function. J Clin Oncol ...

Altered cyclophosphamide and thiotepa pharmacokinetics in a ...

We report a patient with renal insufficiency (creatinine clearance, CLcr = 38 mL/min) who received high-dose chemotherapy with ...

Cancer Drug Dosing in Chronic Kidney Disease and Dialysis

Carboplatin is a second-generation platinum-based chemotherapeutic (including cisplatin, heptaplatin, lobaplatin, nedaplatin, oxaliplatin) used in a variety of ...

summary of product characteristics - TMDA

Blood counts as well as renal and hepatic function tests must be ... carboplatin injection in doses higher than those recommended in patients with renal.

Carboplatin dosing in overweight and obese patients with normal ...

It is suggested that in overweight and obese patients, with a normal renal function, a flat carboplatin dose should be administered, ...

(PDF) Carboplatin dose based on actual renal function: no excess of ...

Introduction The practice of carboplatin dosing is not concordant among different centres and oncologists.

1680-Ovarian recurrent cARBOplatin and gemcitabine (day 1 ... - eviQ

ADDIKD Carboplatin dosing: For dosing carboplatin ... Renal and hepatic dose modifications have been standardised where possible. ... blood cells and renal.

Drug dosing consideration in patients with acute and chronic kidney ...

The conference attendees discussed the major challenges facing drug dosage adjustment for patients with kidney disease. In particular, although glomerular.

An expanded phase I/II trial of cyclophosphamide, etoposide, and ...

Create a Free Account ... carboplatin, and TBI in patients with a spectrum of hematologic malignancies. ... renal dysfunction reported with higher doses of ...

Carboplatin dosing (Calvert formula) - CancerCalc

Approximately 70% of carboplatin is excreted in the urine unchanged after 24 hours, therefore dosing needs to account for renal function. The Calvert ...

Lab Test Interpretation Table - BC Cancer

disease), or reduced renal blood flow (e.g., ... - Certain protocols with medications primarily eliminated via the kidneys (e.g. CISplatin,. CARBOplatin) have ...

Chemotherapy Order Templates - Browse by Cancer Type - NCCN

NCCN Templates enhance patient safety by allowing you to: Standardize patient care; Reduce medication errors; Anticipate and manage adverse events. New! NCCN ...

Furosemide: Uses, Interactions, Mechanism of Action - DrugBank

... renal failure, and high blood pressure. It mainly works by inhibiting electrolyte reabsorption from the kidneys and enhancing the excretion of water from ...

The Effects of Treatment with Interleukin-1α on Platelet Recovery ...

High-dose carboplatin (800 mg per square meter of body-surface area) was administered alone to a control group. Subsequent patients were ...

Drug-induced immune hemolytic anemia - ASH Publications

Ceftriaxone induced hemolysis complicated by acute renal failure. Pediatr Blood Cancer . 2008. ;. 50. : 139. –142. 32.

The Lancet | The best science for better lives

The best science for better lives. Explore the latest high-quality research from The Lancet Group.

Non-Small Cell Lung Cancer Treatment (PDQ®) - NCI

Planned radiation therapy. Planned total dose of cisplatin. ... Chemotherapy significantly prolonged OS for patients older than 65 years (HR, 0.61 ...