Comparing High|Dose Cisplatin Every Three Weeks to Low|Dose ...

NRG-HN009: Randomized Phase II/III Trial of Radiation with High ...

This phase II/III trial compares the effect of the combination of high-dose cisplatin every three weeks and radiation therapy versus low-dose cisplatin weekly ...

Is it acceptable to give weekly cisplatin for patients with - theMednet

Recently published data suggests that weekly cisplatin 30 mg/m2 is inferior to high dose cisplatin (1). In a randomized phase III trial comparing high dose ...

Effects of Concomitant Cisplatin and Radiotherapy on Inoperable ...

Global comparison of all three treatment groups showed that survival improved when cisplatin was combined with radiotherapy (P = 0.054 overall; ...

Ten years survival results of randomized study comparing weekly vs ...

The commonly practiced regimen is weekly cisplatin of dose 40 mg/m2 for 4–6 cycles concurrently with irradiation. In biologically similar ...

Comparison of Safety and Efficacy of Two Different Chemotherapy ...

In the 3 weekly chemotherapy group, the complete response rate after 6 weeks from completion of treatment was 67.7%, which was very promising.

Weekly versus triweekly cisplatin plus intensity-modulated ...

Cisplatin-based concomitant chemo-radiotherapy (CDDP) has been selected as the standard treatment regimen for patients with locally advanced stage NPC [13]. The ...

292-Head and neck SCC locally advanced definitive ciSplatin ... - eviQ

Traditional concomitant chemotherapy regimens include high-dose cisplatin given at 100 mg/m2 every 3 weeks. The authors' purpose was to report efficacy and ...

A meta-analysis comparing cisplatin-based to carboplatin-based ...

The 3-year OS for the cisplatin group was statistically similar to that of the carboplatin group (HR=0.77, 95%CI, 0.58 to 1.03; P=0.08) (Figure ...

Weekly high-dose cisplatin is a feasible treatment option - Nature

Dose reductions were not allowed. Cisplatin single-agent treatment was postponed 1 week for a maximum of 3 weeks if WBC <2.5 × 109 l−1 and ...

HN009 - Illinois CancerCare

Study Summary: This phase II/III trial compares the effect of the combination of high-dose cisplatin every three weeks and radiation therapy versus low-dose ...

Primary Concurrent Chemoradiation in Head and Neck Cancers ...

However, a phase III randomized control trial comparing the standard dose of 100mg/m2 cisplatin tri-weekly with a weekly regimen is needed to establish the long ...

Predictive factors of head and neck squamous cell carcinoma ...

For CCRT, the most well-confirmed chemotherapy regimen in randomized clinical trials (2–4) is high-dose cisplatin, 100 mg/m2 per 3 weeks.

Reduced-Dose Radiation with Cisplatin Improves Outcomes for HPV ...

2-year overall survival rates were 96.7% and 97.3% for the IMRT+C and the IMRT alone arms, respectively. While more grade 3-4 acute toxicities ...

Results of the GORTEC 2015-02 CisFRad randomized trial

Chemo-radiation (CRT) with high dose cisplatin (Cis) 100 mg/m2 q3w (3 cycles) is the standard of care (SOC) in LA-HNSCC. Cumulative delivered dose of Cis is ...

Effect of Standard Radiotherapy With Cisplatin vs Accelerated ...

Objective To compare progression-free survival (PFS) in patients with LA-SCCHN treated with standard-fractionation RT plus high-dose cisplatin ...

Primary Concurrent Chemoradiation in Head and Neck Cancers ...

However, the most widely used concurrent chemoradiation schedule uses high-dose bolus cisplatin. 100mg/m2 every three weeks, in combination with ...

News Post Template - NRG Oncology

Treatment arm 1 was the control arm of 70 Gy of radiation in 6 weeks, 6 fractions per week with cisplatin every 3 weeks. Treatment arm 2 ...

A Randomized Controlled Trial Comparing Two Different Schedules ...

once-every-3-weeks cisplatin group compared to the once-a-week cisplatin ... every-3-weeks regimen reached cumulative dose of 200 mg/m2, while only a ...

Retrospective Analysis of Concurrent Chemoradiation with ...

For weekly CCRT, patients received a median of five chemotherapy cycles and the median total dose of cisplatin was 252 mg/body. No statistically significant ...

Audiological Outcomes of Weekly vs. Triweekly Cisplatin in Head ...

0) after completion of chemoradiation. The high-dose cisplatin regimen significantly increased the ≥grade 3 severe irreversible ototoxicity risk compared to the ...